Immobilizing nanozymes on 3D-printed metal substrates for enhanced peroxidase-like activity and trace-level glucose detection

The prevalence of 3D-printed portable biomedical sensing devices, which are fashioned mainly from plastic and polymer materials, introduces a pressing concern due to their limited reusability and consequential generation of substantial disposable waste. Considering this, herein, we pioneered a groun...

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Bibliographic Details
Published in:Nanoscale 2024-03, Vol.16 (11), p.5561-5573
Main Authors: Koley, Paramita, Jakku, Ranjithkumar, Hosseinnejad, Tayebeh, Periasamy, Selvakannan, Bhargava, Suresh K
Format: Article
Language:English
Subjects:
Biosensing Techniques - methods
Glucose
Glucose - chemistry
Hydrogen Peroxide - chemistry
Iron
Metal-organic frameworks
Oxidation
Oxidation-Reduction
Peroxidase
Peroxidase - chemistry
Peroxidases - metabolism
Portable equipment
Printing, Three-Dimensional
Sensors
Substrates
Three dimensional printing
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Summary:The prevalence of 3D-printed portable biomedical sensing devices, which are fashioned mainly from plastic and polymer materials, introduces a pressing concern due to their limited reusability and consequential generation of substantial disposable waste. Considering this, herein, we pioneered a ground-breaking advancement, i.e. , a 3D-printed metal substrate-based enzyme. Our inventive methodology involved the synthesis of a thermally degraded Fe-based metal-organic framework, DEG 500, followed by its deposition on a 3D-printed metal substrate composed of Ti-Al-V alloy. This novel composite exhibited remarkable peroxidase-like activity in a range of different temperatures and pH, coupled with the ability to detect glucose in real-world samples such as blood and fruit juices. The exceptional enzymatic behaviour was attributed to the diverse iron (Fe) oxidation states and the presence of oxygen vacancies, as evidenced through advanced characterization techniques. Fundamentally, we rigorously explored the mechanistic pathway through controlled studies and theoretical calculations, culminating in a transformative stride toward more sustainable and effective biomedical sensing practices. Development and synthesis of thermally treated metal organic framework-based nanozyme immobilised on 3D-printed metal substrate, which exhibited extraordinary peroxidase-like enzymatic activity and trace-level glucose detection in real samples.
ISSN:2040-3364
2040-3372
DOI:10.1039/d3nr05427f