Irritable bowel syndrome in children: the placebo response rate and influencing factors a meta-analysis

Irritable bowel syndrome is common in children and exhibits a high placebo response. This study was to explore the placebo response rate and its influencing factors in children with irritable bowel syndrome. A systematic search was performed on Pubmed, Embase, MEDLINE, Cochrane Library, CNKI, Wanfan...

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Bibliographic Details
Published in:Pediatric research 2024-05, Vol.95 (6), p.1432-1440
Main Authors: Cai, Li-Li, Li, Xuan, Cai, Qiu-Han, Guo, Sheng-Xuan, Zhang, Yi, Sun, Wen-Cong, Zhao, Ze-Hui, Hu, Si-Yuan
Format: Article
Language:English
Subjects:
Abdominal Pain - drug therapy
Adolescent
Child
Child, Preschool
Childrens health
Clinical outcomes
Clinical trials
Female
Humans
Irritable bowel syndrome
Irritable Bowel Syndrome - drug therapy
Placebo Effect
Placebos
Randomized Controlled Trials as Topic
Response rates
Treatment Outcome
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Summary:Irritable bowel syndrome is common in children and exhibits a high placebo response. This study was to explore the placebo response rate and its influencing factors in children with irritable bowel syndrome. A systematic search was performed on Pubmed, Embase, MEDLINE, Cochrane Library, CNKI, Wanfang, and CBM from database inception to March 2022. Randomized controlled trials of irritable bowel syndrome in children were included in the study. The primary outcome was the placebo response rate of improvement. Thirteen studies were included, with 445 patients in the placebo group. The rate of improvement and abdominal pain disappearance were 28.2% (95% CI, 16.6-39.9%) and 5% (95% CI, 0-18.4%). The placebo response based on the abdominal pain score was 0.675 (95% CI, 0.203-1.147). The mode of administration (P 
ISSN:0031-3998
1530-0447
1530-0447
DOI:10.1038/s41390-023-02996-2