Bougainvillea glabra Choisy bracts extract in free and liposomal forms reduce hyperplasia induced by let‐60gain‐of‐function in Caenorhabditis elegans

In this study, we evaluated the toxicological and antiproliferative effects of B. glabra Choisy bract extract (BGCE) in its free and loaded into liposomes forms administered to C. elegans mutants with let‐60 gain‐of‐function (gf). Our results demonstrated that the concentration up to 75 μg CAE/mL of...

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Bibliographic Details
Published in:Chemistry & biodiversity 2024-02, Vol.21 (2), p.e202300865-n/a
Main Authors: Oliveira Pereira, Flávia Suelen, Oliveira de Souza, Maria Eduarda, Viçozzi, Gabriel Pedroso, Caurio, Aline Castro, Pinton, Simone, Denardin, Cristiane Casagrande, Haas, Sandra Elisa, Gasparotto Denardin, Elton Luis, Ávila, Daiana Silva
Format: Article
Language:English
Subjects:
Animals
Anticancer properties
Apoptosis
bougainvillea
Caenorhabditis elegans - physiology
Caenorhabditis elegans Proteins
cancer
Hyperplasia
insulin-like pathway
Liposomes
Mutants
Nuclear transport
Nyctaginaceae
Ras pathway
Toxicity
Translocation
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Summary:In this study, we evaluated the toxicological and antiproliferative effects of B. glabra Choisy bract extract (BGCE) in its free and loaded into liposomes forms administered to C. elegans mutants with let‐60 gain‐of‐function (gf). Our results demonstrated that the concentration up to 75 μg CAE/mL of BGCE was safe for the worms. Notably, we developed BGCE‐loaded liposomes to extend the pharmacological window up to 100 μg CAE/mL without toxicity. In addition, the extract and liposomes reduced the number and area of the multivulva formed in let‐60 gf mutants. There was also an increase in the apoptotic signaling in the germline cells and increased longevity mediated through DAF‐16 nuclear translocation with GST‐4 activation in the treated animals. Our findings demonstrated that the BGCE‐loaded liposomes possess antitumoral effects due to the activation of the apoptotic signaling and DAF‐16 nuclear translocation.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202300865