Corticotropin-releasing hormone neurons control trigeminal neuralgia-induced anxiodepression via a hippocampus-to-prefrontal circuit

Anxiety and depression are frequently observed in patients suffering from trigeminal neuralgia (TN), but neural circuits and mechanisms underlying this association are poorly understood. Here, we identified a dedicated neural circuit from the ventral hippocampus (vHPC) to the medial prefrontal corte...

Full description

Saved in:

Bibliographic Details
Published in:	Science advances 2024-01, Vol.10 (3), p.eadj4196-eadj4196
Main Authors:	Lv, Su-Su, Lv, Xue-Jing, Cai, Ya-Qi, Hou, Xin-Yu, Zhang, Zhi-Zhe, Wang, Guo-Hong, Chen, Li-Qiang, Lv, Ning, Zhang, Yu-Qiu
Format:	Article
Language:	eng
Subjects:	Corticotropin-Releasing Hormone - metabolism Hippocampus - physiology Humans Neurons - metabolism Pain - metabolism Trigeminal Neuralgia - etiology Trigeminal Neuralgia - metabolism
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Anxiety and depression are frequently observed in patients suffering from trigeminal neuralgia (TN), but neural circuits and mechanisms underlying this association are poorly understood. Here, we identified a dedicated neural circuit from the ventral hippocampus (vHPC) to the medial prefrontal cortex (mPFC) that mediates TN-related anxiodepression. We found that TN caused an increase in excitatory synaptic transmission from vHPC neurons to mPFC inhibitory neurons marked by the expression of corticotropin-releasing hormone (CRH). Activation of CRH neurons subsequently led to feed-forward inhibition of layer V pyramidal neurons in the mPFC via activation of the CRH receptor 1 (CRHR1). Inhibition of the vHPC -mPFC circuit ameliorated TN-induced anxiodepression, whereas activating this pathway sufficiently produced anxiodepressive-like behaviors. Thus, our studies identified a neural pathway driving pain-related anxiodepression and a molecular target for treating pain-related psychiatric disorders.
ISSN:	2375-2548 2375-2548