Fluoride‐treated rare earth‐free magnesium alloy ZK30: An inert and bioresorbable material for bone fracture treatment devices

Bone fractures represent a common health problem, particularly in an increasingly aging population. Bioresorbable magnesium (Mg) alloy‐based implants offer promising alternatives to traditional metallic implants for the treatment of bone fractures because they eliminate the need for implant removal...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2024-07, Vol.112 (7), p.963-972
Main Authors: Watanabe, Hirotaka, Xu, Wei, Uno, Haruka, Uraya, Yuki, Kugita, Masanori, Komohara, Yoshihiro, Niidome, Takuro, Sasaki, Makoto, Shimizu, Ichiro, Fujita, Nobuyuki, Kawano, Yusuke
Format: Article
Language:English
Subjects:
Absorbable Implants
Aging (metallurgy)
Alloys
Alloys - chemistry
Animals
bioabsorbable
Biocompatibility
Biocompatible Materials - chemistry
Biomedical materials
Bone healing
Bone implants
Bones
Corrosion
Corrosion rate
Corrosion resistance
Deformation
fluoride treatment
Fluorides
Fluorides - chemistry
fracture healing
Fractures
Fractures, Bone - therapy
Hydrofluoric acid
intramedullary nail
Magnesium
Magnesium - chemistry
Magnesium - pharmacology
Magnesium base alloys
Male
Materials Testing
Metals
Mg alloy
Mice
Orthopaedic implants
Orthopedics
Transplants & implants
Zirconium base alloys
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Summary:Bone fractures represent a common health problem, particularly in an increasingly aging population. Bioresorbable magnesium (Mg) alloy‐based implants offer promising alternatives to traditional metallic implants for the treatment of bone fractures because they eliminate the need for implant removal after healing. The Mg‐Y‐rare‐earth (RE)‐Zr alloy WE43, designed for orthopedic implants, has received European Conformity mark approval. However, currently, WE43 is not clinically used in certain countries possibly because of concerns related to RE metals. In this study, we investigated the use of a RE‐free alloy, namely, Mg‐Zn‐Zr alloy (ZK30), as an implant for bone fractures. Hydrofluoric acid (HF) treatment was performed to improve the corrosion resistance of ZK30. HF‐treated ZK30 (HF‐ZK30) exhibited lower corrosion rate and higher biocompatibility than those of WE43 in in vitro experiments. After implanting a rod of HF‐ZK30 into the fractured femoral bones of mice, HF‐ZK30 held the bones and healed the fracture without deformation. Treatment results of HF‐ZK30 were comparable to those of WE43, indicating the potential of HF‐ZK30 as a bioresorbable and safe implant for bone repair.
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.37673