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The presence of free palmitic acid modulates the effects of lutein on structural and dynamic properties of lipid membranes
Free fatty acids, like palmitic acid (PA), and xanthophyll pigments, like lutein (LUT) are the natural membrane compounds in plants. To study the effect of PA on LUT and their organization, a model membrane of 1,2-dimyristoyl-sn-glycerol-3-phosphocholine (DMPC) enriched with 2 mol% PA and 1 mol% LUT...
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Published in: | Archives of biochemistry and biophysics 2024-02, Vol.752, p.109883-109883, Article 109883 |
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container_title | Archives of biochemistry and biophysics |
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creator | Reszczyńska, Emilia Wiśniewska-Becker, Anna Duda, Mariusz Sęk, Alicja Gruszecki, Wiesław I Hanaka, Agnieszka |
description | Free fatty acids, like palmitic acid (PA), and xanthophyll pigments, like lutein (LUT) are the natural membrane compounds in plants. To study the effect of PA on LUT and their organization, a model membrane of 1,2-dimyristoyl-sn-glycerol-3-phosphocholine (DMPC) enriched with 2 mol% PA and 1 mol% LUT was formed. Molecular mechanisms underlying the interaction between these two compounds were examined with application of molecular spectroscopy techniques, e.g., visible spectroscopy, electron paramagnetic resonance and Fourier transform infrared. We determined the monomeric/dimeric organization of LUT in the membrane. We proved that the presence of PA in the lipid phase facilitated and stabilized the formation of LUT structures in the membrane. Lutein with PA did not form strong molecular aggregates like H- and J-structures. We presented the simplified model membrane that could be a suitable representation of the physiological process of de-esterification of PA from LUT appearing in natural biomembranes in humans. |
doi_str_mv | 10.1016/j.abb.2024.109883 |
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We presented the simplified model membrane that could be a suitable representation of the physiological process of de-esterification of PA from LUT appearing in natural biomembranes in humans.</description><subject>Dimyristoylphosphatidylcholine - chemistry</subject><subject>Electron Spin Resonance Spectroscopy</subject><subject>Humans</subject><subject>Lipid Bilayers - chemistry</subject><subject>Lipids</subject><subject>Lutein - chemistry</subject><subject>Lutein - pharmacology</subject><subject>Palmitic Acids</subject><subject>Xanthophylls</subject><issn>0003-9861</issn><issn>1096-0384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9kMtOwzAQRS0EoqXwAWyQl2xSxnYezhJVvKRKbLq3bGciUuWF7SzK1-MohdV4rHOvRoeQewZbBix_Om61MVsOPI17KaW4IOv4yBMQMr0kawAQSSlztiI33h8BGEtzfk1WQnLGciHX5OfwhXR06LG3SIea1g7jh267JjSWattUtBuqqdUBPQ0RxrpGG_zMtlPApqdDT31wkw2T0y3VfUWrU6-7GB_dMKILDS54M85t2Bmne_S35KrWrce789yQw-vLYfee7D_fPnbP-8TyTISkxgzAZBWWsrKCYcFKayA3WZHlVcqkNaU0NofUSi4NByFQArdSiCIVshYb8rjUxmO-J_RBdY232LbxhmHyipcsywrOC4goW1DrBu8d1mp0TafdSTFQs3F1VNG4mo2rxXjMPJzrJ9Nh9Z_4Uyx-ASuEfkA</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Reszczyńska, Emilia</creator><creator>Wiśniewska-Becker, Anna</creator><creator>Duda, Mariusz</creator><creator>Sęk, Alicja</creator><creator>Gruszecki, Wiesław I</creator><creator>Hanaka, Agnieszka</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9735-9180</orcidid></search><sort><creationdate>202402</creationdate><title>The presence of free palmitic acid modulates the effects of lutein on structural and dynamic properties of lipid membranes</title><author>Reszczyńska, Emilia ; Wiśniewska-Becker, Anna ; Duda, Mariusz ; Sęk, Alicja ; Gruszecki, Wiesław I ; Hanaka, Agnieszka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c253t-fe500b5de98dc31e719cb06b5756d418cb98bc604c828b2033e802c8337438f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Dimyristoylphosphatidylcholine - chemistry</topic><topic>Electron Spin Resonance Spectroscopy</topic><topic>Humans</topic><topic>Lipid Bilayers - chemistry</topic><topic>Lipids</topic><topic>Lutein - chemistry</topic><topic>Lutein - pharmacology</topic><topic>Palmitic Acids</topic><topic>Xanthophylls</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reszczyńska, Emilia</creatorcontrib><creatorcontrib>Wiśniewska-Becker, Anna</creatorcontrib><creatorcontrib>Duda, Mariusz</creatorcontrib><creatorcontrib>Sęk, Alicja</creatorcontrib><creatorcontrib>Gruszecki, Wiesław I</creatorcontrib><creatorcontrib>Hanaka, Agnieszka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reszczyńska, Emilia</au><au>Wiśniewska-Becker, Anna</au><au>Duda, Mariusz</au><au>Sęk, Alicja</au><au>Gruszecki, Wiesław I</au><au>Hanaka, Agnieszka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The presence of free palmitic acid modulates the effects of lutein on structural and dynamic properties of lipid membranes</atitle><jtitle>Archives of biochemistry and biophysics</jtitle><addtitle>Arch Biochem Biophys</addtitle><date>2024-02</date><risdate>2024</risdate><volume>752</volume><spage>109883</spage><epage>109883</epage><pages>109883-109883</pages><artnum>109883</artnum><issn>0003-9861</issn><eissn>1096-0384</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Free fatty acids, like palmitic acid (PA), and xanthophyll pigments, like lutein (LUT) are the natural membrane compounds in plants. 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We presented the simplified model membrane that could be a suitable representation of the physiological process of de-esterification of PA from LUT appearing in natural biomembranes in humans.</abstract><cop>United States</cop><pmid>38211638</pmid><doi>10.1016/j.abb.2024.109883</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-9735-9180</orcidid></addata></record> |
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subjects | Dimyristoylphosphatidylcholine - chemistry Electron Spin Resonance Spectroscopy Humans Lipid Bilayers - chemistry Lipids Lutein - chemistry Lutein - pharmacology Palmitic Acids Xanthophylls |
title | The presence of free palmitic acid modulates the effects of lutein on structural and dynamic properties of lipid membranes |
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