Anti-SARS-CoV-2 Activity of a Polyphenolic Complex from Maackia amurensis

We studied the ability of the polyphenolic complex from Maackia amurensis , the active substance of Maksar, to inhibit the cytopathogenic effect induced by the SARS-CoV-2 and to reduce the concentration of viral RNA in infected Vero E6 cells. Polyphenolic complex showed significant anti-SARS-CoV-2 a...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2023-12, Vol.176 (2), p.187-190
Main Authors: Krylova, N. V., Iunikhina, O. V., Fedoreev, S. A., Pott, A. B., Persiyanova, E. V., Mishchenko, N. P., Tarbeeva, D. V., Shchelkanov, M. Y.
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents - pharmacology
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell culture
Chlorocebus aethiops
COVID-19
Cytotoxicity
Immunology
Infections
Internal Medicine
Laboratory Medicine
Maackia
Maackia amurensis
Pathology
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Vero Cells
Viral infections
Virus Replication
Viruses
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Summary:We studied the ability of the polyphenolic complex from Maackia amurensis , the active substance of Maksar, to inhibit the cytopathogenic effect induced by the SARS-CoV-2 and to reduce the concentration of viral RNA in infected Vero E6 cells. Polyphenolic complex showed significant anti-SARS-CoV-2 activity and effectively inhibited viral replication by direct action on viral particles and the early stage of viral infection.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-024-05992-6