Recyclable and Environmentally Friendly Magnetic Nanoparticles with Aggregation-Induced Emission Photosensitizer for Sustainable Bacterial Inactivation in Water

Bacterial photodynamic inactivation based on the combined actions of photosensitizers, light, and oxygen presents a promising alternative for eliminating bacteria compared to conventional water disinfection methods. However, a significant challenge in this approach is the inability to retrieve photo...

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Bibliographic Details
Published in:ACS nano 2024-01, Vol.18 (3), p.1907-1920
Main Authors: Yu, Eric Y., Chau, Joe H. C., Lee, Michelle M. S., Koo, Tsin Hei, Lortz, Rolf, Lam, Jacky W. Y., Kwok, Ryan T. K., Li, Yuanyuan, Tang, Ben Zhong
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Gram-Negative Bacteria
Gram-Positive Bacteria
Magnetite Nanoparticles
Nanoparticles
Photochemotherapy - methods
Photosensitizing Agents - pharmacology
Photosensitizing Agents - therapeutic use
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Summary:Bacterial photodynamic inactivation based on the combined actions of photosensitizers, light, and oxygen presents a promising alternative for eliminating bacteria compared to conventional water disinfection methods. However, a significant challenge in this approach is the inability to retrieve photosensitizers after phototreatment, posing potential adverse environmental impacts. Additionally, conventional photosensitizers often exhibit limited photostability and photodynamic efficiency. This study addresses these challenges by employing an aggregation-induced emission (AIE) photosensitizer, iron oxide magnetic nanoparticles (Fe3O4 MNPs), and Pluronic F127 to fabricate AIE magnetic nanoparticles (AIE MNPs). AIE MNPs not only exhibit fluorescence imaging capabilities and superior photosensitizing ability but also demonstrate broad-spectrum bactericidal activities against both Gram-positive and Gram-negative bacteria. The controlled release of TPA-Py-PhMe and magnetic characteristics of the AIE MNPs facilitate reuse and recycling for multiple cycles of bacterial inactivation in water. Our findings contribute valuable insights into developing environmentally friendly disinfectants, emphasizing the full potential of AIE photosensitizers in photodynamic inactivation beyond biomedical applications.
ISSN:1936-0851
1936-086X
DOI:10.1021/acsnano.3c05941