Breast surgery after neoadjuvant chemotherapy in patients with lobular carcinoma: surgical and oncologic outcome

Introduction Breast cancer patients with invasive lobular carcinoma (ILC) have an increased risk of positive margins after surgery and often show little response to neoadjuvant chemotherapy (NAC). We aimed to investigate surgical outcomes in patients with ILC treated with NAC. Methods In this retros...

Full description

Saved in:
Bibliographic Details
Published in:Breast cancer research and treatment 2024-04, Vol.204 (3), p.497-507
Main Authors: van Hemert, Annemiek, van Loevezijn, Ariane A., Bosman, Anne, Vlahu, Carmen A., Loo, Claudette E., Peeters, Marie-Jeanne T. F. D. Vrancken, van Duijnhoven, Frederieke H., van der Ploeg, Iris M. C.
Format: Article
Language:English
Subjects:
Biopsy
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Carcinoma
Carcinoma, Ductal, Breast - pathology
Carcinoma, Lobular - drug therapy
Carcinoma, Lobular - pathology
Carcinoma, Lobular - surgery
Chemotherapy
Clinical Trial
Female
Humans
Margins of Excision
Mastectomy
Mastectomy, Segmental
Medicine
Medicine & Public Health
Neoadjuvant Therapy
Neoplasm Recurrence, Local - surgery
Oncology
Retrospective Studies
Surgery
Surgical outcomes
Survival
Tumors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Breast cancer patients with invasive lobular carcinoma (ILC) have an increased risk of positive margins after surgery and often show little response to neoadjuvant chemotherapy (NAC). We aimed to investigate surgical outcomes in patients with ILC treated with NAC. Methods In this retrospective cohort study, all breast cancer patients with ILC treated with NAC who underwent surgery at the Netherlands Cancer Institute from 2010 to 2019 were selected. Patients with mixed type ILC in pre-NAC biopsies were excluded if the lobular component was not confirmed in the surgical specimen. Main outcomes were tumor-positive margins and re-excision rate. Associations between baseline characteristics and tumor-positive margins were assessed, as were complications, locoregional recurrence rate (LRR), recurrence-free survival (RFS), and overall survival (OS). Results We included 191 patients. After NAC, 107 (56%) patients had breast conserving surgery (BCS) and 84 (44%) patients underwent mastectomy. Tumor-positive margins were observed in 67 (35%) patients. Fifty five (51%) had BCS and 12 (14%) underwent mastectomy ( p value 
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-023-07192-8