Utility of Early Magnetic Resonance Imaging to Enhance Outcome Prediction in Critically Ill Children with Severe Traumatic Brain Injury

Background Many children with severe traumatic brain injury (TBI) receive magnetic resonance imaging (MRI) during hospitalization. There are insufficient data on how different patterns of injury on early MRI inform outcomes. Methods Children (3–17 years) admitted in 2010–2021 for severe TBI (Glasgow...

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Published in:Neurocritical care 2024-08, Vol.41 (1), p.80-90
Main Authors: Janas, Anna M., Miller, Kristen R., Stence, Nicholas V., Wyrwa, Jordan M., Ruzas, Christopher M., Messer, Ricka, Mourani, Peter M., Fink, Ericka L., Maddux, Aline B.
Format: Article
Language:English
Subjects:
Age groups
Brain research
Critical Care Medicine
Edema
Intensive
Internal Medicine
Magnetic resonance imaging
Medical imaging
Medical prognosis
Medicine
Medicine & Public Health
Neuroimaging
Neurology
Neurosurgery
Original Work
Patients
Pediatrics
Rehabilitation
Trauma
Traumatic brain injury
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Summary:Background Many children with severe traumatic brain injury (TBI) receive magnetic resonance imaging (MRI) during hospitalization. There are insufficient data on how different patterns of injury on early MRI inform outcomes. Methods Children (3–17 years) admitted in 2010–2021 for severe TBI (Glasgow Coma Scale [GCS] score  38 °C) in the first 12 h. Results Of 260 patients, 136 (52%) underwent MRI within 7 days of injury at a median of 3 days (interquartile range [IQR] 2–4). Patients with early MRI were a median age of 11 years (IQR 7–14), 8 (6%) patients received cardiopulmonary resuscitation, 19 (14%) patients had bilateral unreactive pupils, the median motor GCS score was 1 (IQR 1–4), and 82 (60%) patients had fever. Grade 3 DAI was present in 46 (34%) patients, and restricted diffusion was noted in the corpus callosum in 75 (55%) patients, deep gray matter in 29 (21%) patients, subcortical white matter in 23 (17%) patients, and the brainstem in 20 (15%) patients. After controlling for clinical variables, an increased number of regions with restricted diffusion, but not hemorrhagic DAI grade, was independently associated with longer time to follow commands (hazard ratio 0.68, 95% confidence interval 0.53–0.89) and worse WeeFIM scores (estimate β  − 4.67, 95% confidence interval − 8.33 to − 1.01). Conclusions Regional restricted diffusion on early MRI is independently associated with short-term outcomes in children with severe TBI. Multicenter cohort studies are needed to validate these findings and elucidate the association of early MRI features with long-term outcomes in children with severe TBI.
ISSN:1541-6933
1556-0961
1556-0961
DOI:10.1007/s12028-023-01898-9