Evaluation of silver nanoparticle-impregnated PMMA loaded with vancomycin or gentamicin against bacterial biofilm formation

Bone cement containing vancomycin or gentamicin is a therapeutic strategy for combating orthopedic infections: however, the activity of these antibiotics is narrow. Silver nanoparticles (AgNPs) are nanocomponents with a wide spectrum, including multidrug-resistant bacteria. In the present study, we...

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Bibliographic Details
Published in:Injury 2023-11, Vol.54 Suppl 6, p.110649-110649, Article 110649
Main Authors: Soni, Jamil Faissal, Ribeiro, Victoria Stadler Tasca, Cieslinski, Juliette, de Andrade, Ana Paula, Dantas, Letícia Ramos, Pereira, Bruna Zanatta, de Almeida, Beatriz Martins Rodrigues Carvalho, Suss, Paula Hansen, Tuon, Felipe Francisco
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Bacteria
Biofilms
Bone Cements - pharmacology
Escherichia coli
Gentamicins - pharmacology
Humans
Metal Nanoparticles
Polymethyl Methacrylate - pharmacology
Silver - pharmacology
Staphylococcus aureus
Vancomycin - pharmacology
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Summary:Bone cement containing vancomycin or gentamicin is a therapeutic strategy for combating orthopedic infections: however, the activity of these antibiotics is narrow. Silver nanoparticles (AgNPs) are nanocomponents with a wide spectrum, including multidrug-resistant bacteria. In the present study, we aimed to evaluate the effect of AgNP-loaded polymethylmethacrylate (PMMA) on biofilm formation by Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus epidermidis. The effect of AgNP-loaded PMMA with and without vancomycin or gentamicin on biofilm production was quantitatively analyzed. S. aureus, E. coli, P. aeruginosa, and S. epidermidis were included as biofilm-producing microorganisms in the in vitro model. AgNP-loaded PMMA with antibiotics reduced the number of colony-forming units (CFUs; p
ISSN:0020-1383
1879-0267
DOI:10.1016/j.injury.2023.02.032