Metabolome implies increased fatty acid utilization and histone methylation in the follicles from hyperandrogenic PCOS women

Well-balanced metabolism is essential for the high-quality of oocytes, and metabolic fluctuations of follicular microenvironment potentially encourage functional changes in follicle cells, ultimately impacting the developmental potential of oocytes. Here, the global metabolomic profiles of follicula...

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Bibliographic Details
Published in:The Journal of nutritional biochemistry 2024-03, Vol.125, p.109548-109548, Article 109548
Main Authors: Xu, Yue, Zhou, Zhiyang, Zhang, Gaochen, Yang, Zuwei, Shi, Yan, Jiang, Zhaoying, Liu, Ye, Chen, Huixi, Huang, Hefeng, Zhang, Yu, Pan, Jiexue
Format: Article
Language:English
Subjects:
androgen
Androgens
fatty acid
Fatty Acids
Female
follicular fluid
Histones - metabolism
Humans
metabolic profiles
Metabolome
Methylation
polycystic ovary syndrome
Polycystic Ovary Syndrome - metabolism
Pregnancy
Tumor Microenvironment
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Summary:Well-balanced metabolism is essential for the high-quality of oocytes, and metabolic fluctuations of follicular microenvironment potentially encourage functional changes in follicle cells, ultimately impacting the developmental potential of oocytes. Here, the global metabolomic profiles of follicular fluid from PCOS women with ovarian hyperandrogenism and nonhyperandrogenism were depicted by untargeted metabolome and transcriptome. In parallel, functional methods were employed to evaluate the possible impact of dysregulated metabolites on oocyte and embryo development. Our findings demonstrated that PCOS women exhibited distinct metabolic features in follicles, such as the increase in fatty acid utilization and the downregulation in amino acid metabolism. And intrafollicular androgen levels were positively correlated with contents of multiple fatty acids, suggesting androgen as one of the contributing factors to the metabolic abnormalities in PCOS follicles. Moreover, we further demonstrated that elevated levels of α-linolenic acid and H3K27me3 could hinder oocyte maturation, fertilization, and early embryo development. Hopefully, our data serve as a broad resource on the metabolic abnormalities of PCOS follicles, and advances in the relevant knowledge will allow the identification of biomarkers that predict the progression of PCOS and its poor pregnancy outcomes.
ISSN:0955-2863
1873-4847
DOI:10.1016/j.jnutbio.2023.109548