Exercise-Induced Transient Oxidative Stress Is Mitigated in Down Syndrome: Insights About Redox Balance and Muscle Strength

Reis, AL, Deus, LA, Neves, RVP, Corrêa, HL Reis, TL, Aguiar, LS Honorato, FS, Barbosa, JMS, Araújo, TB, Palmeira, TRC, Simões, HG, Prestes, J, Sousa, CV, Ide, BN, and Rosa, TdS. Exercise-induced transient oxidative stress is mitigated in Down syndrome: insights about redox balance and muscle strengt...

Full description

Saved in:
Bibliographic Details
Published in:Journal of strength and conditioning research 2024-03, Vol.38 (3), p.e125-e134
Main Authors: Reis, Andrea Lucena, Deus, Lysleine Alves, Passos Neves, Rodrigo Vanerson, Corrêa, Hugo de Luca, Reis, Thaís Lucena, Aguiar, Lucas Soares de, Honorato, Fernando Sousa, Barbosa, Jessica Mycaelle da Silva, Araújo, Thaís Branquinho de, Palmeira, Thalyta Railine Cesar, Simões, Herbert Gustavo, Prestes, Jonato, Sousa, Caio Victor, Ide, Bernardo Neme, Rosa, Thiago Dos Santos
Format: Article
Language:English
Subjects:
Acute effects
Allantoin
Body composition
Body height
Body mass index
Down Syndrome
Down's syndrome
Elbow
Hand Strength
Humans
Inflammation
Interleukin 10
Knee
Muscle contraction
Muscle strength
Muscle Strength - physiology
Muscle, Skeletal - physiology
Oxidative stress
Resistance Training
Saliva
Tumor Necrosis Factor-alpha
Tumor necrosis factor-α
Uric Acid
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Reis, AL, Deus, LA, Neves, RVP, Corrêa, HL Reis, TL, Aguiar, LS Honorato, FS, Barbosa, JMS, Araújo, TB, Palmeira, TRC, Simões, HG, Prestes, J, Sousa, CV, Ide, BN, and Rosa, TdS. Exercise-induced transient oxidative stress is mitigated in Down syndrome: insights about redox balance and muscle strength. J Strength Cond Res 38(3): e125-e34, 2024-This study aimed to evaluate the acute effects of a session of resistance exercise (RE) performed with elastic tubes on the redox balance and inflammatory profile in individuals with Down syndrome (DS). Subjects ( n = 23) were allocated into 2 groups: individuals with DS (DS; n = 11) and individuals without DS (WDS; n = 12), who performed an acute RE session. Diagnostic assessment included medical history, anthropometric measures (body height, body mass, body mass index, and body composition assessment), biological collections, muscle strength assessments (handgrip and maximal voluntary isometric contraction tests), and exercises. The redox balance and inflammatory profile were assessed in urine and saliva samples before and after an acute RE session. There were no differences between WDS and DS groups for body composition ( p > 0.05). The DS group presented higher values pre and post an acute RE session with elastic tubes for oxidative and proinflammatory markers compared with WDS ( p < 0.05). Uric acid values increased from pre-acute RE session to post-acute RE session for WDS ( p < 0.0001). No differences were identified within groups for the delta analysis ( p > 0.05). Inverse correlations were found between total force and F2-isoprostane, 8OHdG, uric acid, allantoin, IL-6, TNF-α, and the TNF-α:IL-10 ratio. A positive correlation was found between IL-10 and total force. The DS group presented increased peak force in the knee extension and elbow flexion exercises (∼25 and 12%, respectively) but decreases in handgrip strength of ∼7%. The WDS group showed higher peak force values for knee extension, elbow flexion, and handgrip (∼16, 10, and 14%, respectively). The DS group had lower transient elevation of oxidative stress after an acute RE session compared with WDS. Oxidative stress and inflammation responses of DS to an acute RE session with elastic tubes may be insufficient to induce health adaptations for the same relative load compared with WDS.
ISSN:1064-8011
1533-4287
DOI:10.1519/JSC.0000000000004664