Effect of Nk-lysin peptides on bacterial growth, MIC, antimicrobial resistance, and viral activities

NK-lysins from chicken, bovine and human are used as antiviral and antibacterial agents. Gram-negative and gram-positive microorganisms, including and , are susceptible to NK-lysin treatment. The presence of dominant TEM-1 gene was noted in all untreated and treated bacteria, while TOHO-1 gene was a...

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Bibliographic Details
Published in:Animal biotechnology 2024-11, Vol.35 (1), p.2290520-2290520
Main Authors: Yacoub, Haitham A, Mahmoud, Maged Mostafa, Al-Hejin, Ahmed M, Abujamel, Turki S, Tabrez, Shams, Abd-Elmaksoud, Sherif
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Antiviral Agents
beta-Lactamases - pharmacology
Cattle
Drug Resistance, Bacterial
Escherichia coli
Humans
Peptides - chemistry
Peptides - pharmacology
Proteolipids
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Summary:NK-lysins from chicken, bovine and human are used as antiviral and antibacterial agents. Gram-negative and gram-positive microorganisms, including and , are susceptible to NK-lysin treatment. The presence of dominant TEM-1 gene was noted in all untreated and treated bacteria, while TOHO-1 gene was absent in all bacteria. Importantly, β-lactamase genes CTX-M-1, CTX-M-8, and CTX-M-9 genes were detected in untreated bacterial strains; however, none of these were found in any bacterial strains following treatment with NK-lysin peptides. NK-lysin peptides are also used to test for inhibition of infectivity, which ranged from 50 to 90% depending on NK-lysin species. Chicken, bo vine and human NK-lysin peptides are demonstrated herein to have antibacterial activity and antiviral activity against Rotavirus (strain SA-11). On the basis of the comparison between these peptides, potent antiviral activity of bovine NK-lysin against Rotavirus (strain SA-11) is particularly evident, inhibiting infection by up to 90%. However, growth was also significantly inhibited by chicken and human NK-lysin peptides, restricted by 80 and 50%, respectively. This study provided a novel treatment using NK-lysin peptides to inhibit expression of β-lactamase genes in β-lactam antibiotic-resistant bacterial infections.
ISSN:1049-5398
1532-2378
DOI:10.1080/10495398.2023.2290520