Cellular senescence in brain aging and neurodegeneration

Cellular senescence is a state of terminal cell cycle arrest associated with various macromolecular changes and a hypersecretory phenotype. In the brain, senescent cells naturally accumulate during aging and at sites of age-related pathologies. Here, we discuss the recent advances in understanding t...

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Bibliographic Details
Published in:	Ageing research reviews 2024-01, Vol.93, p.102141-102141, Article 102141
Main Authors:	Melo Dos Santos, L S, Trombetta-Lima, M, Eggen, Bjl, Demaria, M
Format:	Article
Language:	eng
Subjects:	Aging - physiology Brain - physiology Cell Cycle Checkpoints Cellular Senescence - physiology Humans Neurodegenerative Diseases
Online Access:	Get full text
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Summary:	Cellular senescence is a state of terminal cell cycle arrest associated with various macromolecular changes and a hypersecretory phenotype. In the brain, senescent cells naturally accumulate during aging and at sites of age-related pathologies. Here, we discuss the recent advances in understanding the accumulation of senescent cells in brain aging and disorders. Here we highlight the phenotypical heterogeneity of different senescent brain cell types, highlighting the potential importance of subtype-specific features for physiology and pathology. We provide a comprehensive overview of various senescent cell types in naturally occurring aging and the most common neurodegenerative disorders. Finally, we critically discuss the potential of adapting senotherapeutics to improve brain health and reduce pathological progression, addressing limitations and future directions for application and development.
ISSN:	1568-1637 1872-9649