Monoclonal antibody-navigated carbon-encapsulated iron nanoparticles used for MRI-based tracking integrin receptors in murine melanoma

Integrin beta-3 is a cell adhesion molecule that mediate cell-to-cell and cell-to-extracellular matrix communication. The major goal of this study was to explore melanoma cells (B16F10) based upon specific direct targeting of the β3 subunit (CD61) in the integrin αvβ3 receptor using carbon-encapsula...

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Bibliographic Details
Published in:Nanomedicine 2024-01, Vol.55, p.102721-102721, Article 102721
Main Authors: Bamburowicz-Klimkowska, Magdalena, Bystrzejewski, Michal, Kasprzak, Artur, Cieszanowski, Andrzej, Grudzinski, Ireneusz P
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - pharmacology
Antineoplastic Agents - pharmacology
Carbon - therapeutic use
Cell Adhesion
Integrin alphaVbeta3 - metabolism
Iron - pharmacology
Magnetic Resonance Imaging
Melanoma - diagnostic imaging
Melanoma - drug therapy
Melanoma - metabolism
Mice
Mice, Inbred C57BL
Nanoparticles
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Summary:Integrin beta-3 is a cell adhesion molecule that mediate cell-to-cell and cell-to-extracellular matrix communication. The major goal of this study was to explore melanoma cells (B16F10) based upon specific direct targeting of the β3 subunit (CD61) in the integrin αvβ3 receptor using carbon-encapsulated iron nanoparticles decorated with monoclonal antibodies (Fe@C-CONH-anti-CD61 and Fe@C-(CH ) -CONH-anti-CD61). Both melanoma cells treated with nanoparticles as well as C57BL/6 mice bearing syngeneic B16-F10 tumors intravenously injected with nanoparticles were tested in preclinical MRI studies. The as-synthesized carbon-encapsulated iron nanoparticles functionalized with CD61 monoclonal antibodies have been successfully used as a novel targeted contrast agent for MRI-based tracking melanoma cells expressing the β3 subunit of the integrin αvβ3 receptor.
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2023.102721