Timing to Surgery and Lymph Node Upstaging in Gastric Cancer: An NCDB Analysis

Background Prior studies have shown tumor specificity on the impact of longer time interval from diagnosis to surgery, however in gastric cancer (GC) this remains unclear. We aimed to determine if a longer time interval from diagnosis to surgery had an impact on lymph node (LN) upstaging and overall...

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Bibliographic Details
Published in:Annals of surgical oncology 2024-03, Vol.31 (3), p.1714-1724
Main Authors: Riascos, Maria Cristina, Greenberg, Jacques A., Palacardo, Federico, Edelmuth, Rodrigo, Lewis, V. Colby, An, Anjile, Najah, Haythem, Al Asadi, Hala, Safe, Parima, Finnerty, Brendan M., Christos, Paul J., Fahey, Thomas J., Zarnegar, Rasa
Format: Article
Language:English
Subjects:
Diagnosis
Gastric cancer
Gastrointestinal Oncology
Humans
Lymph Node Excision
Lymph nodes
Lymph Nodes - pathology
Lymphatic system
Medicine
Medicine & Public Health
Multivariate Analysis
Neoplasm Staging
Oncology
Patients
Proportional Hazards Models
Regression analysis
Retrospective Studies
Stomach Neoplasms - pathology
Surgery
Surgical Oncology
Survival
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Summary:Background Prior studies have shown tumor specificity on the impact of longer time interval from diagnosis to surgery, however in gastric cancer (GC) this remains unclear. We aimed to determine if a longer time interval from diagnosis to surgery had an impact on lymph node (LN) upstaging and overall survival (OS) outcomes among patients with clinically node negative (cN0) GC. Patients and Methods Patients diagnosed with cN0 GC undergoing surgery between 2004–2018 were identified in the National Cancer Database (NCDB) and divided into intervals between time of diagnosis and surgery [short interval (SI): ≥ 4 days to < 8 weeks and long interval (LI): ≥ 8 weeks]. Multivariable regression analysis evaluated the independent impact of surgical timing on LN upstaging and a Cox proportional hazards analysis and Kaplan–Meier curves evaluated survival outcomes. Results Of 1824 patients with cN0 GC, 71.8% had a SI to surgery and 28.1% had a LI to surgery. LN upstaging was seen more often in the SI group when compared to LI group (82% versus 76%, p = 0.004). LI to surgery showed to be an independent factor protective against LN upstaging [adjusted odds ratio = 0.62, 95% CI: (0.39–0.99)]. Multivariate Cox regression analysis indicated that time to surgery was not associated with a difference in overall survival [hazard ratio (HR) = 0.91, 95% CI: (0.71–1.17)], however uncontrolled Kaplan–Meier curves showed OS difference between the SI and LI to surgery groups ( p = 0.037). Conclusion Timing to surgery was not a predictor of LN upstaging or overall survival, suggesting that additional medical optimization in preparation for surgery and careful preoperative staging may be appropriate in patients with node negative early stage GC without affecting outcomes.
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-023-14536-7