Altered Impulsivity Across Drug‐Naïve Parkinsonism, Isolated Rapid Eye Movement Sleep Behavior Disorder, and Their High‐Risk Relatives

Objective To determine multidimensional impulsivity levels across different early stages of α‐synucleinopathy. Methods This cross‐sectional study investigated motor and decisional impulsivity levels using a panel of computerized tasks among drug‐naïve parkinsonism patients, isolated/idiopathic rapid...

Full description

Saved in:
Bibliographic Details
Published in:Annals of neurology 2024-03, Vol.95 (3), p.544-557
Main Authors: Zhou, Li, Li, Shirley Xin, Chau, Steven WH, Huang, Bei, Wang, Jing, Tang, Shi, Chan, Joey WY, Zhang, Jihui, Yu, Mandy WM, Tsang, Jessie CC, Hu, Michele TM, Mok, Vincent CT, Wing, Yun Kwok, Liu, Yaping
Format: Article
Language:English
Subjects:
Balloon treatment
Basal ganglia
Behavior disorders
Central nervous system diseases
Cross-Sectional Studies
Dopamine receptors
Eye movements
Humans
Impulsive Behavior
Impulsivity
Movement disorders
Multidimensional methods
Parkinsonian Disorders
Patients
REM sleep
REM Sleep Behavior Disorder
Risk levels
Risk reduction
Risk taking
Sleep
Sleep disorders
Synucleinopathies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To determine multidimensional impulsivity levels across different early stages of α‐synucleinopathy. Methods This cross‐sectional study investigated motor and decisional impulsivity levels using a panel of computerized tasks among drug‐naïve parkinsonism patients, isolated/idiopathic rapid eye movement sleep behavior disorder (iRBD) patients and their first‐degree relatives (iRBD‐FDRs), and control participants. Trait impulsivity and impulse control behaviors were assessed by self‐reported questionnaires. Results A total of 27 drug‐naïve parkinsonism patients, 157 iRBD patients, 66 iRBD‐FDRs, and 82 control participants were recruited. Parkinsonism and iRBD patients had fewer numbers of extracted beads in beads task 1 and 2 (both p 
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.26836