Engineering Copper‐Containing Nanoparticles‐Loaded Silicene Nanosheets with Triple Enzyme Mimicry Activities and Photothermal Effect for Promoting Bacteria‐Infected Wound Healing

Skin wounds accompanied by bacterial infections threaten human health, and conventional antibiotic treatments are ineffective for drug‐resistant bacterial infections and chronically infected wounds. The development of non‐antibiotic‐dependent therapeutics is highly desired but remains a challenging...

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Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-04, Vol.20 (15), p.e2307096-n/a
Main Authors: Zeng, Junkai, Gu, Changjiang, Geng, Xiangwu, Wang, Zhong‐Yi, Xiong, Zhi‐Chao, Zhu, Ying‐Jie, Chen, Xiongsheng
Format: Article
Language:English
Subjects:
Angiogenesis
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
antibacterial
Antibiotics
Bacteria
Bacterial Infections
Biocompatibility
Biomedical materials
Catalase
Catalysis
Copper
Copper converters
Endothelial cells
Enzymes
Humans
Methicillin-Resistant Staphylococcus aureus
Mimicry
Nanoparticles
Nanosheets
nanozymes
Peroxidase
Photothermal conversion
Silicene
silicene nanosheets
Staphylococcus infections
Synergistic effect
Wound Healing
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Summary:Skin wounds accompanied by bacterial infections threaten human health, and conventional antibiotic treatments are ineffective for drug‐resistant bacterial infections and chronically infected wounds. The development of non‐antibiotic‐dependent therapeutics is highly desired but remains a challenging issue. Recently, 2D silicene nanosheets with considerable biocompatibility, biodegradability, and photothermal‐conversion performance have received increasing attention in biomedical fields. Herein, copper‐containing nanoparticles‐loaded silicene (Cu2.8O@silicene‐BSA) nanosheets with triple enzyme mimicry catalytic (peroxidase, catalase, and oxidase‐like) activities and photothermal function are rationally designed and fabricated for efficient bacterial elimination, angiogenesis promotion, and accelerated wound healing. Cu2.8O@silicene‐BSA nanosheets display excellent antibacterial activity through synergistic effects of reactive oxygen species generated from multiple catalytic reactions, intrinsic bactericidal activity of released Cu2+ ions, and photothermal effects, achieving high antibacterial efficiencies on methicillin‐resistant Staphylococcus aureus (MRSA) of 99.1 ± 0.7% in vitro and 97.2 ± 1.6% in vivo. In addition, Cu2.8O@silicene‐BSA nanosheets exhibit high biocompatibility for promoting human umbilical vein endothelial cell (HUVEC) proliferation and angiogenic differentiation. In vivo experiments reveal that Cu2.8O@silicene‐BSA nanosheets with synergistic photothermal/chemodynamic therapeutics effectively accelerate MRSA‐infected wound healing by eliminating bacteria, alleviating inflammation, boosting collagen deposition, and promoting angiogenesis. This research presents a promising strategy to engineer photothermal‐assisted nanozyme catalysis for bacteria‐invaded wound healing. Copper‐containing nanoparticles‐loaded silicene (Cu2.8O@silicene‐BSA) nanosheets with triple enzyme mimicry catalytic (peroxidase, catalase, and oxidase‐like) activities and photothermal function are rationally fabricated for efficient bacterial elimination, angiogenesis promotion, and accelerated wound healing. Owing to the generation of ROS and hyperthermia under NIR laser irradiation, they demonstrate the capability to eliminate methicillin‐resistant Staphylococcus aureus (MRSA), showing potential benefits for bacteria‐invaded wound healing.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202307096