Untangling the web of intratumor microbiota in lung cancer

Microbes are pivotal in contemporary cancer research, influencing various biological behaviors in cancer. The previous notion that the lung was sterile has been destabilized by the discovery of microbiota in the lower airway and lung, even within tumor tissues. Advances of biotechnology enable the a...

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Published in:Biochimica et biophysica acta. Reviews on cancer 2023-11, Vol.1878 (6), p.189025-189025, Article 189025
Main Authors: Liu, Weici, Xu, Jingtong, Pi, Zheshun, Chen, Yundi, Jiang, Guanyu, Wan, Yuan, Mao, Wenjun
Format: Article
Language:English
Subjects:
Bacterial translocation
Biomarkers
Biotechnology
Cancer treatment
Carcinogenesis
Humans
Immuno-oncology-microbiome axis
Intratumor microbiota
Lung - pathology
Lung Neoplasms - pathology
Microbial biomarker
Microbiota
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Summary:Microbes are pivotal in contemporary cancer research, influencing various biological behaviors in cancer. The previous notion that the lung was sterile has been destabilized by the discovery of microbiota in the lower airway and lung, even within tumor tissues. Advances of biotechnology enable the association between intratumor microbiota and lung cancer to be revealed. Nonetheless, the origin and tumorigenicity of intratumor microbiota in lung cancer still remain implicit. Additionally, accumulating evidence indicates that intratumor microbiota might serve as an emerging biomarker for cancer diagnosis, prognosis, and even a therapeutic target across multiple cancer types, including lung cancer. However, research on intratumor microbiota's role in lung cancer is still nascent and warrants more profound exploration. Herein, this paper provides an extensive review of recent advancements in the following fields, including 1) established and emerging biotechnologies utilized to study intratumor microbiota in lung cancer, 2) causation between intratumor microbiota and lung cancer from the perspectives of translocation, cancerogenesis and metastasis, 3) potential application of intratumor microbiota as a novel biomarker for lung cancer diagnosis and prognosis, and 4) promising lung cancer therapies via regulating intratumor microbiota. Moreover, this review addresses the limitations, challenges, and future prospects of studies focused on intratumor microbiota in lung cancer. [Display omitted] •The integration of diverse biotechnologies assists in depicting the signatures of intratumor microbiota.•The mechanistic causality between intratumor microbiota and lung cancer is explored from multiple perspectives.•Intratumor microbes can function as potential biomarkers for lung cancer diagnosis and prognosis.•Regulating intratumor microbiota might be a promising therapy to reshape the therapeutic landscape of lung cancer.
ISSN:0304-419X
1879-2561
DOI:10.1016/j.bbcan.2023.189025