Cytosolic nucleic acid sensing and mitochondrial transcriptomic changes as early triggers of metabolic disease in db/db mice

Animal models of diabetes, such as db/db mice, are a useful tool for deciphering the genetic background of molecular changes at the initial stages of disease development. Our goal was to find early transcriptomic changes in three tissues involved in metabolism regulation in db/db mice: adipose tissu...

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Bibliographic Details

Published in:	Mammalian genome 2024-03, Vol.35 (1), p.68-76
Main Authors:	Ludwig-Słomczyńska, Agnieszka H., Seweryn, Michał T., Wiater, Jerzy, Borys, Agnieszka, Ledwoń, Anna, Druszczyńska, Magdalena, Łabieniec-Watała, Magdalena, Lis, Grzegorz J., Wołkow, Paweł P.
Format:	Article
Language:	eng
Subjects:	Adipose tissue Age Animal Genetics and Genomics Animal models Animals Antigens, Surface Biomedical and Life Sciences Cell Biology Developmental stages Diabetes Diabetes Mellitus Gene expression Gene Expression Profiling Human Genetics Immune response Interferon regulatory factor 7 Life Sciences Liver Membrane Glycoproteins Metabolic disorders Mice Mice, Inbred Strains Mitochondria Nucleic Acids Signal transduction Stat2 protein Transcriptome Transcriptomes Transcriptomics
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