Dyslipidemia and cardiovascular disease among childhood cancer survivors: a St. Jude Lifetime Cohort report

Childhood cancer survivors have increased risk of dyslipidemia and atherosclerotic cardiovascular disease (CVD). The aim of this study was to evaluate the prevalence and associated cardiovascular risks of specific lipid abnormalities among childhood cancer survivors. Comprehensive lipid panel measur...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 2024-03, Vol.116 (3), p.408-420
Main Authors: Goldberg, Jason F, Hyun, Geehong, Ness, Kirsten K, Dixon, Stephanie B, Towbin, Jeffrey A, Rhea, Isaac B, Ehrhardt, Matthew J, Srivastava, Deo Kumar, Mulrooney, Daniel A, Hudson, Melissa M, Robison, Leslie L, Jefferies, John L, Rohatgi, Anand, Armstrong, Gregory T
Format: Article
Language:English
Subjects:
Cancer Survivors
Cardiomyopathies - complications
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Child
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Dyslipidemias - complications
Dyslipidemias - etiology
Female
Humans
Male
Myocardial Infarction - complications
Neoplasms - complications
Neoplasms - epidemiology
Risk Factors
Triglycerides
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Summary:Childhood cancer survivors have increased risk of dyslipidemia and atherosclerotic cardiovascular disease (CVD). The aim of this study was to evaluate the prevalence and associated cardiovascular risks of specific lipid abnormalities among childhood cancer survivors. Comprehensive lipid panel measurements were obtained from 4115 5-year survivors, with 3406 (mean age at evaluation = 35.2 years, SD = 10.4 years) not having previous dyslipidemia diagnosis, as well as 624 age, sex, and race and ethnicity matched community controls. Previously undiagnosed dyslipidemia with abnormal low-density lipoprotein (LDL) cholesterol (>160 mg/dL), non-high density lipoprotein (HDL) cholesterol (>190 mg/dL), HDL cholesterol (
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/djad222