Key Predictors of Epilepsy-Specific Health-Related Quality of Life (HRQOL) in Youth with Epilepsy

•Caregiver proxy-report and youth self-reported health-related quality of life provide a comprehensive understanding of functioning in youth with epilepsy.•Mental and behavioral health symptoms uniquely impact caregiver proxy-report and youth self-reported health-related quality of life.•Routine psy...

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Bibliographic Details
Published in:Epilepsy & behavior 2023-12, Vol.149, p.109508-109508, Article 109508
Main Authors: Brothers, Shannon L., Clifford, Lisa M., Guilfoyle, Shanna M., Wagner, Janelle L., Junger, Katherine, Huszti, Heather, Modi, Avani C.
Format: Article
Language:English
Subjects:
Adolescent
Caregiver-proxy
Child
Cognition
Epilepsy
Epilepsy - psychology
Executive Function
Health-Related Quality of Life
Humans
Mental and Behavioral Health
Pediatric
Quality of Life - psychology
Seizures
Surveys and Questionnaires
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Summary:•Caregiver proxy-report and youth self-reported health-related quality of life provide a comprehensive understanding of functioning in youth with epilepsy.•Mental and behavioral health symptoms uniquely impact caregiver proxy-report and youth self-reported health-related quality of life.•Routine psychosocial screening is critical for the proactive treatment of mental and behavioral health symptoms. Epilepsy-specific health-related quality of life (HRQOL) is an important outcome in youth with epilepsy (YWE). The PedsQLTM Epilepsy Module is the only caregiver-proxy and youth self-report epilepsy-specific HRQOL measure that can be used with youth 2-25 years. Multiple factors affect HRQOL, including epilepsy-specific characteristics, comorbid mental and behavioral health concerns, as well as sociodemographic factors. However, we have not yet examined the cumulative impact of these factors on epilepsy-specific HRQOL in YWE using the PedsQLTM Epilepsy module. Youth with epilepsy (n=281) and their caregivers completed questionnaires focused on sociodemographic factors (e.g., youth biological sex and age), mood/anxiety and behavior symptoms (i.e., Behavioral Assessment Scale for Children – Second Edition; BASC-2, Parent Rating Scale), epilepsy characteristics [e.g., seizure frequency, number of anti-seizure medications (ASMs), ASM side effects, and years since diagnosis], and the PedsQLTM Epilepsy module (subscalesImpact, Cognitive Functioning, Executive Functioning, Sleep, and Mood/Behavior). Hierarchical linear regressions were conducted to examine caregiver-proxy and youth self-reported factors that affect epilepsy-specific HRQOL. Results indicate the strongest key shared predictors of HRQOL in YWE, for both youth and caregiver informants, were mental and behavioral health symptoms. For instance, caregiver-proxy report of YWE HRQOL indicated BASC-2 Externalizing (p
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2023.109508