Higher atherogenic risk in schoolchildren is associated with MTMR9 rs2293855 gene polymorphism and genetic score

Abstract Childhood dyslipidaemia is associated with the occurrence of cardiovascular diseases in adulthood, so evaluating whether an individual has a genetic predisposition to this pathology is of great importance for early action of prevention and treatment. This study aimed to evaluate the associa...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition bulletin 2023-12, Vol.48 (4), p.559-571
Main Authors: Silva, Mariane Alves, Resende, Cristina Maria Mendes, Louro, Maíra Barros, Ribeiro, Sarah Aparecida Vieira, do Carmo Castro Franceschini, Sylvia, Velasquez‐Melendez, Gustavo, Alvarez‐Leite, Jacqueline Isaura, Durso, Danielle Fernandes, de Novaes, Juliana Farias
Format: Article
Language:English
Subjects:
Body composition
Body height
Cardiovascular diseases
Children
Cholesterol
Dual energy X-ray absorptiometry
Dyslipidemia
Gene polymorphism
Genotyping
High density lipoprotein
Lipoproteins
Low density lipoprotein
Metabolic disorders
Obesity
Polymorphism
Single-nucleotide polymorphism
Triglycerides
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Childhood dyslipidaemia is associated with the occurrence of cardiovascular diseases in adulthood, so evaluating whether an individual has a genetic predisposition to this pathology is of great importance for early action of prevention and treatment. This study aimed to evaluate the association between the FTO (rs9939609), MC4R (rs17782313) and MTMR9 (rs2293855) polymorphisms, the obesity‐related genetic risk score and atherogenic risk in Brazilian children. This is a cross‐sectional study conducted in 544 children aged 4–9 years in the city of Viçosa, Minas Gerais state, Brazil. The single nucleotide polymorphisms rs9939609, rs17782313 and rs2293855 , were identified by the system TaqMan SNP genotyping and the obesity‐related genetic risk score was determined. The lipid profile (serum total cholesterol [TC], high density lipoprotein [HDL] cholesterol, low density lipoprotein [LDL] cholesterol, triglycerides) was analysed and the atherogenic indices (Castelli I and II indices), atherogenic coefficient (AC), lipoprotein combined index (LCI) and plasma atherogenic index (PAI) were calculated. A semi‐structured questionnaire was applied, obtaining data on the sociodemographic, economic and lifestyle characteristics of the children. Weight and height measurements were performed in all children, and body composition was evaluated by Dual‐Energy X‐ray Absorptiometry (DXA). 55.5% of the sample had dyslipidaemia, while 28.5% of the sample had at least one polymorphism and 2.2% had three polymorphisms. Children with the AG/AA genotypes in the rs2293855 polymorphism had lower HDL cholesterol levels and higher TC/HDL cholesterol, LDL/HDL cholesterol ratios and AC. Those with one or more polymorphisms (rs9939609, rs17782313 and rs229385 5 ) in the genetic risk score had lower HDL cholesterol levels and higher TC/HDL cholesterol ratios, AC, LCI and PAI. In conclusion, the risk allele of the rs2293855 polymorphism and a higher obesity‐related genetic risk score were positively associated with higher atherogenic risk in Brazilian children.
ISSN:1471-9827
1467-3010
DOI:10.1111/nbu.12644