Photoreactive silver-containing supramolecular polymers that form self-assembled nanogels for efficient antibacterial treatment

Photo-crosslinked silver-containing supramolecular polymers could offer an effective therapeutic strategy for bacterial infections that not only facilitate accelerated release of silver ions within the bacterial microenvironment, but also induce massive programmed cell death in bacteria. [Display om...

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Bibliographic Details
Published in:Journal of colloid and interface science 2024-01, Vol.654, p.967-978
Main Authors: Fesseha, Yohannes Asmare, Manayia, Abere Habtamu, Liu, Ping-Cheng, Su, Ting-Hsuan, Huang, Sin-Yu, Chiu, Chih-Wei, Cheng, Chih-Chia
Format: Article
Language:English
Subjects:
Cytosine-Silver-Cytosine Complex
Enhanced Antibacterial Activity
Photodimerization
Self-assembled Nanogel
Silver-Based Metallo-supramolecular Polymer
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Summary:Photo-crosslinked silver-containing supramolecular polymers could offer an effective therapeutic strategy for bacterial infections that not only facilitate accelerated release of silver ions within the bacterial microenvironment, but also induce massive programmed cell death in bacteria. [Display omitted] •Photoreactive silver-containing supramolecular polymer (Ag-Cy-PPG) was developed.•UV-irradiated Ag-Cy-PPG self-assembles into spherical-like nanogels in water.•Irradiated nanogels exhibit unique phase transition and photophysical properties.•Irradiated nanogels exert strong antibacterial activity.•This new system has potential for effective antibacterial therapy. In this study, an efficient synthetic strategy and potential route to obtain a photo-reactive silver-containing cytosine-functionalized polypropylene glycol polymer (Ag-Cy-PPG) was developed by combining a hydrophilic oligomeric polypropylene glycol (PPG) backbone with dual pH-sensitive/photo-reactive cytosine-silver-cytosine (Cy-Ag-Cy) linkages. The resulting photo-responsive Ag-Cy-PPG holds great promise as a multifunctional biomedical material that generates spherical-like nanogels in water; the nanogels exhibit high antibacterial activity and thus may significantly enhance the efficacy of antibacterial treatment. Due to the formation of photo-dimerized Cy-Ag-Cy cross-linkages after UV irradiation, Ag-Cy-PPG converts into water-soluble cross-linked nanogels that possess a series of interesting chemical and physical properties, such as intense and stable fluorescence behavior, highly sensitive pH-responsive characteristics, on/off switchable phase transition behavior, and well-controlled release of silver ions (Ag+) in mildly acidic aqueous solution. Importantly, antibacterial tests clearly demonstrated that irradiated Ag-Cy-PPG nanogels exhibited strong antibacterial activity at low doses (MIC values of 
ISSN:0021-9797
1095-7103
DOI:10.1016/j.jcis.2023.10.119