Characteristics of Gastric Mucosa-Associated Microbiota in Patients with Early Gastric Cancer After Successful Helicobacter pylori Eradication

Background Helicobacter pylori ( H. pylori ) is widely recognized as a definite carcinogen in gastric cancer (GC). Although H. pylori eradication reduces the risk of GC, GC recurrence has been detected even after successful H. pylori eradication. Recently, the analysis of gut microbiota was reported...

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Published in:Digestive diseases and sciences 2023-12, Vol.68 (12), p.4398-4406
Main Authors: Nakano, Takahiro, Dohi, Osamu, Takagi, Tomohisa, Naito, Yuji, Fukui, Hayato, Miyazaki, Hajime, Yasuda, Takeshi, Yoshida, Takuma, Azuma, Yuka, Ishida, Tsugitaka, Kitae, Hiroaki, Matsumura, Shinya, Takayama, Shun, Mizuno, Naoki, Kashiwagi, Saori, Mizushima, Katsura, Inoue, Ryo, Doi, Toshifumi, Hirose, Ryohei, Inoue, Ken, Yoshida, Naohisa, Kamada, Kazuhiro, Uchiyama, Kazuhiko, Ishikawa, Takeshi, Konishi, Hideyuki, Itoh, Yoshito
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Language:English
Subjects:
Biochemistry
Gastric cancer
Gastroenterology
Hepatology
Medicine
Medicine & Public Health
Microbiota
Oncology
Original Article
Transplant Surgery
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creator Nakano, Takahiro
Dohi, Osamu
Takagi, Tomohisa
Naito, Yuji
Fukui, Hayato
Miyazaki, Hajime
Yasuda, Takeshi
Yoshida, Takuma
Azuma, Yuka
Ishida, Tsugitaka
Kitae, Hiroaki
Matsumura, Shinya
Takayama, Shun
Mizuno, Naoki
Kashiwagi, Saori
Mizushima, Katsura
Inoue, Ryo
Doi, Toshifumi
Hirose, Ryohei
Inoue, Ken
Yoshida, Naohisa
Kamada, Kazuhiro
Uchiyama, Kazuhiko
Ishikawa, Takeshi
Konishi, Hideyuki
Itoh, Yoshito
description Background Helicobacter pylori ( H. pylori ) is widely recognized as a definite carcinogen in gastric cancer (GC). Although H. pylori eradication reduces the risk of GC, GC recurrence has been detected even after successful H. pylori eradication. Recently, the analysis of gut microbiota was reported. Aims This study aimed to evaluate the correlation between gastric mucosa-associated microbiota (G-MAM) and early gastric cancer (EGC) after successful H. pylori eradication. Methods In this pilot study, G-MAM were collected during the esophagogastroduodenoscopy of 17 patients, receiving H. pylori eradication therapy at least 5 years ago. The patients were divided into those with EGC (the EGC group, 8 patients) and those without EGC (the NGC group, 9 patients). Microbial samples in the greater curvature of the pyloric site were obtained using an endoscopic cytology brush, and the G-MAM profiles of each sample were analyzed using 16S rRNA V3-V4 gene sequencing. Results Between the two groups, there was no significant difference in the median age, sex, median period after successful eradication of H. pylori , the α diversity, and the average abundance at the phylum level. At the genus level, the average abundance of Unclassified Oxalobacteraceae , Capnocytophaga , and Haemophilus was significantly lower in the EGC group than in the NGC group (0.89 vs. 0.14%, P  
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Although H. pylori eradication reduces the risk of GC, GC recurrence has been detected even after successful H. pylori eradication. Recently, the analysis of gut microbiota was reported. Aims This study aimed to evaluate the correlation between gastric mucosa-associated microbiota (G-MAM) and early gastric cancer (EGC) after successful H. pylori eradication. Methods In this pilot study, G-MAM were collected during the esophagogastroduodenoscopy of 17 patients, receiving H. pylori eradication therapy at least 5 years ago. The patients were divided into those with EGC (the EGC group, 8 patients) and those without EGC (the NGC group, 9 patients). Microbial samples in the greater curvature of the pyloric site were obtained using an endoscopic cytology brush, and the G-MAM profiles of each sample were analyzed using 16S rRNA V3-V4 gene sequencing. Results Between the two groups, there was no significant difference in the median age, sex, median period after successful eradication of H. pylori , the α diversity, and the average abundance at the phylum level. At the genus level, the average abundance of Unclassified Oxalobacteraceae , Capnocytophaga , and Haemophilus was significantly lower in the EGC group than in the NGC group (0.89 vs. 0.14%, P  &lt; 0.01, 0.28 vs. 0.00%, P  &lt; 0.01 and 5.84 vs. 2.16%, P  = 0.034, respectively). Conclusions We demonstrated alternations in the profiles of G-MAM between the two groups. Our results suggest that G-MAM may influence carcinogenesis after successful H. pylori eradication.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-023-08154-2</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biochemistry ; Gastric cancer ; Gastroenterology ; Hepatology ; Medicine ; Medicine &amp; Public Health ; Microbiota ; Oncology ; Original Article ; Transplant Surgery</subject><ispartof>Digestive diseases and sciences, 2023-12, Vol.68 (12), p.4398-4406</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-5422dbfff2e1151d8284c9b6a5df984e9cfd03b8d2a5f860c4fac750687f8d1f3</citedby><cites>FETCH-LOGICAL-c352t-5422dbfff2e1151d8284c9b6a5df984e9cfd03b8d2a5f860c4fac750687f8d1f3</cites><orcidid>0000-0002-0498-0144</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids></links><search><creatorcontrib>Nakano, Takahiro</creatorcontrib><creatorcontrib>Dohi, Osamu</creatorcontrib><creatorcontrib>Takagi, Tomohisa</creatorcontrib><creatorcontrib>Naito, Yuji</creatorcontrib><creatorcontrib>Fukui, Hayato</creatorcontrib><creatorcontrib>Miyazaki, Hajime</creatorcontrib><creatorcontrib>Yasuda, Takeshi</creatorcontrib><creatorcontrib>Yoshida, Takuma</creatorcontrib><creatorcontrib>Azuma, Yuka</creatorcontrib><creatorcontrib>Ishida, Tsugitaka</creatorcontrib><creatorcontrib>Kitae, Hiroaki</creatorcontrib><creatorcontrib>Matsumura, Shinya</creatorcontrib><creatorcontrib>Takayama, Shun</creatorcontrib><creatorcontrib>Mizuno, Naoki</creatorcontrib><creatorcontrib>Kashiwagi, Saori</creatorcontrib><creatorcontrib>Mizushima, Katsura</creatorcontrib><creatorcontrib>Inoue, Ryo</creatorcontrib><creatorcontrib>Doi, Toshifumi</creatorcontrib><creatorcontrib>Hirose, Ryohei</creatorcontrib><creatorcontrib>Inoue, Ken</creatorcontrib><creatorcontrib>Yoshida, Naohisa</creatorcontrib><creatorcontrib>Kamada, Kazuhiro</creatorcontrib><creatorcontrib>Uchiyama, Kazuhiko</creatorcontrib><creatorcontrib>Ishikawa, Takeshi</creatorcontrib><creatorcontrib>Konishi, Hideyuki</creatorcontrib><creatorcontrib>Itoh, Yoshito</creatorcontrib><title>Characteristics of Gastric Mucosa-Associated Microbiota in Patients with Early Gastric Cancer After Successful Helicobacter pylori Eradication</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>Background Helicobacter pylori ( H. pylori ) is widely recognized as a definite carcinogen in gastric cancer (GC). Although H. pylori eradication reduces the risk of GC, GC recurrence has been detected even after successful H. pylori eradication. Recently, the analysis of gut microbiota was reported. Aims This study aimed to evaluate the correlation between gastric mucosa-associated microbiota (G-MAM) and early gastric cancer (EGC) after successful H. pylori eradication. Methods In this pilot study, G-MAM were collected during the esophagogastroduodenoscopy of 17 patients, receiving H. pylori eradication therapy at least 5 years ago. The patients were divided into those with EGC (the EGC group, 8 patients) and those without EGC (the NGC group, 9 patients). Microbial samples in the greater curvature of the pyloric site were obtained using an endoscopic cytology brush, and the G-MAM profiles of each sample were analyzed using 16S rRNA V3-V4 gene sequencing. 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Although H. pylori eradication reduces the risk of GC, GC recurrence has been detected even after successful H. pylori eradication. Recently, the analysis of gut microbiota was reported. Aims This study aimed to evaluate the correlation between gastric mucosa-associated microbiota (G-MAM) and early gastric cancer (EGC) after successful H. pylori eradication. Methods In this pilot study, G-MAM were collected during the esophagogastroduodenoscopy of 17 patients, receiving H. pylori eradication therapy at least 5 years ago. The patients were divided into those with EGC (the EGC group, 8 patients) and those without EGC (the NGC group, 9 patients). Microbial samples in the greater curvature of the pyloric site were obtained using an endoscopic cytology brush, and the G-MAM profiles of each sample were analyzed using 16S rRNA V3-V4 gene sequencing. 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subjects Biochemistry
Gastric cancer
Gastroenterology
Hepatology
Medicine
Medicine & Public Health
Microbiota
Oncology
Original Article
Transplant Surgery
title Characteristics of Gastric Mucosa-Associated Microbiota in Patients with Early Gastric Cancer After Successful Helicobacter pylori Eradication
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