Motility induced phase separation of deformable cells

Using a multi-phase field model, we examine how particle deformability, which is a proxy for cell stiffness, affects motility induced phase separation (MIPS). We show that purely repulsive deformable, i.e. , squishy, cells phase separate more effectively than their rigid counterparts. This can be un...

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Bibliographic Details
Published in:Soft matter 2023-11, Vol.19 (42), p.8172-8178
Main Authors: Hopkins, Austin, Loewe, Benjamin, Chiang, Michael, Marenduzzo, Davide, Marchetti, M. Cristina
Format: Article
Language:English
Subjects:
Deformability
Deformation effects
Formability
Phase separation
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Summary:Using a multi-phase field model, we examine how particle deformability, which is a proxy for cell stiffness, affects motility induced phase separation (MIPS). We show that purely repulsive deformable, i.e. , squishy, cells phase separate more effectively than their rigid counterparts. This can be understood as due to the fact that deformability increases the effective duration of collisions. In addition, the dense regions become increasingly disordered as deformability increases. Our results contextualize the applicability of MIPS to biological systems and have implications for how cells in biological systems may self-organize. Using a multi-phase field model, we examine how cell stiffness affects motility induced phase separation (MIPS).
ISSN:1744-683X
1744-6848
DOI:10.1039/d3sm01059g