Inflammation and cardiometabolic diseases induced by persistent organic pollutants and nutritional interventions: Effects of multi-organ interactions

The development and outcome of inflammatory diseases are associated with genetic and lifestyle factors, which include chemical and nonchemical stressors. Persistent organic pollutants (POPs) are major groups of chemical stressors. For example, dioxin-like polychlorinated biphenyls (PCBs), per- and p...

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Published in:Environmental pollution (1987) 2023-12, Vol.339, p.122756-122756, Article 122756
Main Authors: Wang, Zhongmin, Zhou, Yixuan, Xiao, Xia, Liu, Aowen, Wang, Shengnan, Preston, RogerJ.S., Zaytseva, Yekaterina Y., He, Guangzhao, Xiao, Wenjin, Hennig, Bernhard, Deng, Pan
Format: Article
Language:English
Subjects:
Cardiovascular Diseases - chemically induced
Environmental Pollutants - analysis
Environmental Pollutants - toxicity
Halogenated Diphenyl Ethers - analysis
Halogenated Diphenyl Ethers - toxicity
Humans
Inflammation - chemically induced
Intervention
Multi-organ
PBDE
PCB
Persistent Organic Pollutants
PFAS
Polychlorinated Biphenyls - analysis
Polychlorinated Biphenyls - toxicity
Toxicity
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Summary:The development and outcome of inflammatory diseases are associated with genetic and lifestyle factors, which include chemical and nonchemical stressors. Persistent organic pollutants (POPs) are major groups of chemical stressors. For example, dioxin-like polychlorinated biphenyls (PCBs), per- and polyfluoroalkyl substances (PFASs), and polybrominated diphenyl ethers (PBDEs) are closely associated with the incidence of inflammatory diseases. The pathology of environmental chemical-mediated inflammatory diseases is complex and may involve disturbances in multiple organs, including the gut, liver, brain, vascular tissues, and immune systems. Recent studies suggested that diet-derived nutrients (e.g., phytochemicals, vitamins, unsaturated fatty acids, dietary fibers) could modulate environmental insults and affect disease development, progression, and outcome. In this article, mechanisms of environmental pollutant-induced inflammation and cardiometabolic diseases are reviewed, focusing on multi-organ interplays and highlighting recent advances in nutritional strategies to improve the outcome of cardiometabolic diseases associated with environmental exposures. In addition, advanced system biology approaches are discussed, which present unique opportunities to unveil the complex interactions among multiple organs and to fuel the development of precision intervention strategies in exposed individuals. [Display omitted] •Organ interactions play important roles in POPs-induced inflammatory diseases.•A complex network of interactions exists between host organs and gut/microbiome.•Nutritional intervention strategies should consider multiple organ interactions.
ISSN:0269-7491
1873-6424
DOI:10.1016/j.envpol.2023.122756