Circulating glypican-4 is a new predictor of all-cause mortality in patients with heart failure

[Display omitted] •GPC4 is positively correlated with NT-proBNP•High serum GPC4 predicts all-cause mortality in heart failure patients.•GPC4 predicts mortality risk independently from other risk factors.•GPC4 shows additional predictive value to NT-proBNP for all-cause mortality. Heart failure confe...

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Bibliographic Details
Published in:Clinical biochemistry 2023-11, Vol.121-122, p.110675-110675, Article 110675
Main Authors: Muendlein, Axel, Heinzle, Christine, Leiherer, Andreas, Brandtner, Eva Maria, Geiger, Kathrin, Gaenger, Stella, Fraunberger, Peter, Mader, Arthur, Saely, Christoph H., Drexel, Heinz
Format: Article
Language:English
Subjects:
Biomarker
Glypican-4, NT-proBNP
Heart failure
Mortality
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Summary:[Display omitted] •GPC4 is positively correlated with NT-proBNP•High serum GPC4 predicts all-cause mortality in heart failure patients.•GPC4 predicts mortality risk independently from other risk factors.•GPC4 shows additional predictive value to NT-proBNP for all-cause mortality. Heart failure confers a high burden of morbidity and mortality. However, risk prediction in heart failure patients still is limited. Blood-based biomarkers hold promise to improve clinical risk assessment. Recently we have identified circulating glypican-4 (GPC4) as a significant predictor of mortality in coronary angiography patients and patients with peripheral artery disease. The impact of serum GPC4 on mortality in patients with heart failure is unknown and is addressed in this prospective cohort study. We prospectively recorded all-cause mortality in 288 patients with heart failure. GPC4 levels were measured using an enzyme-linked immunosorbent assay at baseline. During the 24-month follow-up period, 28.1% (n = 81) of the patients died. Serum GPC4 significantly predicted all-cause mortality (hazard ratio (HR) per doublingof GPC4 = 3.57 [2.31–5.53]; P 
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2023.110675