Erythrocyte glutathione transferase. A sensitive Up-Down biomarker of environmental and industrial pollution

Erythrocyte glutathione transferase is a well-known biomarker of environmental pollution. Examination of the extensive scientific literature discovers an atypical and very interesting property of this enzyme which may reveal a chronic exposition to many contaminants but in some cases even an acute a...

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Bibliographic Details
Published in:Archives of biochemistry and biophysics 2023-12, Vol.750, p.109786-109786, Article 109786
Main Authors: Bocedi, Alessio, Gambardella, Giorgia, Cattani, Giada, Notari, Sara, Ricci, Giorgio
Format: Article
Language:English
Subjects:
Animal model
Biomarker
Biomarkers
Environmental Pollution
Erythrocytes
Glutathione
Glutathione Transferase
Industrial pollution
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Summary:Erythrocyte glutathione transferase is a well-known biomarker of environmental pollution. Examination of the extensive scientific literature discovers an atypical and very interesting property of this enzyme which may reveal a chronic exposition to many contaminants but in some cases even an acute and short-term dangerous contamination. This review also underlines the peculiar molecular and kinetic properties of this enzyme which makes it unique in the panorama of enzymes used as biomarker for environmental contamination. [Display omitted] •GSTP1-1 is expressed in the erythrocyte and in others animal tissues.•e-GST is a biomarker for environmental and industrial pollution.•e-GST is expressed or inhibited after exposure of the organism to toxic compounds.
ISSN:0003-9861
1096-0384
DOI:10.1016/j.abb.2023.109786