Dielectric properties of urine in relation to bladder cancer

Many studies have investigated the dielectric properties of human and animal tissues, particularly to differentiate between normal cells and tumors. However, these studies are invasive as tissue samples have to be excised to measure the properties. This study aims to investigate the dielectric prope...

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Published in:	Physical and engineering sciences in medicine 2024-03, Vol.47 (1), p.61-71
Main Authors:	Zhu, Chao-Zhe, Ting, Hua-Nong, Ng, Kwan-Hoong, Mun, Kein-Seong, Ong, Teng-Aik
Format:	Article
Language:	eng
Subjects:	Biological and Medical Physics Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biophysics Cytodiagnosis Epithelial Cells - pathology Humans Medical and Radiation Physics ROC Curve Scientific Paper Urinalysis Urinary Bladder Neoplasms - diagnosis Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - urine
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Summary:	Many studies have investigated the dielectric properties of human and animal tissues, particularly to differentiate between normal cells and tumors. However, these studies are invasive as tissue samples have to be excised to measure the properties. This study aims to investigate the dielectric properties of urine in relation to bladder cancer, which is safe and non-invasive to patients. 30 healthy subjects and 30 bladder cancer patients were recruited. Their urine samples were subjected to urinalysis and cytology assessment. A vector network analyzer was used to measure the dielectric constant (Ɛ′) and loss factor (Ɛ″) at microwave frequencies of between 0.2 and 50 GHz at 25 °C, 30 °C and 37 °C. Significant differences in Ɛ′ and Ɛ″ were observed between healthy subjects and patients, especially at frequencies of between 25 and 40 GHz at 25 °C. Bladder cancer patients had significant lower Ɛ′ and higher Ɛ″ compared with healthy subjects. The Ɛ′ was negatively correlated with urinary exfoliated urothelial cell number, and Ɛ″ was positively correlated. The study achieved a receiver operating characteristic area under curve (ROC–AUC) score of 0.69099 and an optimum accuracy of 75% with a sensitivity of 80% and a specificity of 70%. The number of exfoliated urothelial cell had significant effect on the dielectric properties, especially in bladder cancer patients. Urinary dielectric properties could potentially be used as a tool to detect bladder cancer.
ISSN:	2662-4729 2662-4737