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The gut microbiome in the fight against obesity: The potential of dietary factors
Obesity as a global public health burden has experienced a drastic growing trend recently. The management of obesity is challenging because of its complex etiology, and various factors are involved in its development, such as genetic and environmental factors. Different approaches are available to t...
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Published in: | The FASEB journal 2023-11, Vol.37 (11), p.e23258-n/a |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Obesity as a global public health burden has experienced a drastic growing trend recently. The management of obesity is challenging because of its complex etiology, and various factors are involved in its development, such as genetic and environmental factors. Different approaches are available to treat and/or manage obesity, including diet, physical activity, lifestyle changes, medications, and surgery. However, some of these approaches have inherent limitations and are closely associated with adverse effects. Therefore, probing into a novel/safe approach to treat and/or manage obesity is of fundamental importance. One such approach gaining renewed interest is the potential role of gut microbiota in obesity and its effectiveness in treating this condition. However, there is a dearth of comprehensive compilation of data on the potential role of the gut microbiome in obesity, particularly regarding dietary factors as a therapeutic approach. Therefore, this review aims to provide an updated overview of the role of gut microbiota in obesity, further highlighting the importance of dietary factors, particularly diet, prebiotics, and probiotics, as potential complementary and/or alternative therapeutic options. Moreover, the association of gut microbiota with obese or lean individuals has also been discussed.
Obesity is a global public health burden with complex etiology, and various factors are involved in its development. Different approaches are available to treat and/or manage obesity, but they have limitations and adverse effects. The gut microbiota is a novel target for obesity treatment. Dietary factors, including diet, prebiotics, and probiotics, may be important for gut microbiota health and obesity management. This review provides an overview of the role of gut microbiota in obesity and the importance of dietary factors. |
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ISSN: | 0892-6638 1530-6860 |
DOI: | 10.1096/fj.202300864RR |