TRIP6 disrupts tight junctions to promote metastasis and drug resistance and is a therapeutic target in colorectal cancer

Metastasis is the primary cause of death in colorectal cancer (CRC). Thyroid hormone receptor interacting protein 6 (TRIP6) is an adaptor protein that regulates cell motility. Here, we aim to elucidate the role of TRIP6 in driving CRC tumorigenesis and metastasis and evaluate its potential as a ther...

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Bibliographic Details
Published in:Cancer letters 2023-12, Vol.578, p.216438-216438, Article 216438
Main Authors: Gou, Hongyan, Wong, Chi Chun, Chen, Huarong, Shang, Haiyun, Su, Hao, Zhai, Jianning, Liu, Weixin, Liu, Wenxiu, Sun, Donglei, Wang, Xin, Yu, Jun
Format: Article
Language:English
Subjects:
Chemotherapy
Colorectal cancer
Epithelial-mesenchymal transition
Tight junction
TRIP6
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Summary:Metastasis is the primary cause of death in colorectal cancer (CRC). Thyroid hormone receptor interacting protein 6 (TRIP6) is an adaptor protein that regulates cell motility. Here, we aim to elucidate the role of TRIP6 in driving CRC tumorigenesis and metastasis and evaluate its potential as a therapeutic target. TRIP6 mRNA is up-regulated in CRC compared to adjacent normal tissues in three independent cohorts (all P 
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2023.216438