Coronaviruses spike glycoprotein endodomains: The sequence and structure‐based comprehensive study

Any protein's flexibility or region makes it available to interact with many biomolecules in the cell. Specifically, such interactions in viruses help them to perform more functions despite having a smaller genome. Therefore, these flexible regions can be exciting and essential targets to be ex...

Full description

Saved in:
Bibliographic Details
Published in:Protein science 2023-11, Vol.32 (11), p.e4804-n/a
Main Authors: Kumar, Prateek, Bhardwaj, Aparna, Mukherjee, Bodhidipra, Joshi, Richa, Giri, Rajanish
Format: Article
Language:English
Subjects:
Bioinformatics
Biomolecules
Coronaviridae
Coronaviruses
COVID-19
Dynamic structural analysis
Genomes
Glycoproteins
intrinsic disorder regions (IDRs)
Molecular dynamics
molecular dynamics simulations
molecular recognition features (MoRFs)
Pathogenicity
Pathogens
post‐translational modifications
Protein structure
Proteins
Severe acute respiratory syndrome coronavirus 2
Spike glycoprotein
Spike protein
Therapeutic applications
Viruses
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Any protein's flexibility or region makes it available to interact with many biomolecules in the cell. Specifically, such interactions in viruses help them to perform more functions despite having a smaller genome. Therefore, these flexible regions can be exciting and essential targets to be explored for their role in pathogenicity and therapeutic developments as they achieve essential interactions. In the continuation with our previous study on disordered analysis of SARS‐CoV‐2 spike protein's cytoplasmic tail (CTR), or endodomain, here we have explored the endodomain's disordered potential of six other coronaviruses using multiple bioinformatics approaches and molecular dynamics simulations. Based on the comprehensive analysis of its sequence and structural composition, we report the varying disorder propensity in endodomains of spike proteins of coronaviruses. The observations of this study may help to understand the importance of spike glycoprotein endodomain and creating therapeutic interventions against them.
ISSN:0961-8368
1469-896X
DOI:10.1002/pro.4804