Lycium barbarum polysaccharide inhibits blue‐light‐induced skin oxidative damage with the involvement of mitophagy

Although blue light can damage the skin to a certain extent, the pathogenesis of its damage remains still unclear. The available evidence suggests that oxidative stress may be the main cause of its damage. Lycium barbarum polysaccharide (LBP) has antioxidative effects in a variety of cells. In this...

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Bibliographic Details
Published in:Photochemistry and photobiology 2024-05, Vol.100 (3), p.604-621
Main Authors: Wu, Fen, Dang, Bingrong, Hu, Liming, Zhu, Sen, Liu, Zuohao, Cao, Xinhui, Li, Zhen, Wang, Chunming, Lin, Changjun
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Apoptosis
Apoptosis - drug effects
Autophagy
blue light
Calcium (intracellular)
Calcium ions
Cell Line
Drugs, Chinese Herbal - pharmacology
HaCaT Cells
Humans
Irradiation
Light
Light - adverse effects
Light irradiation
Lycium barbarum
Lycium barbarum polysaccharide
Membrane potential
Membrane Potential, Mitochondrial - drug effects
Mice
Mitochondria
Mitophagy
Mitophagy - drug effects
Mitophagy - radiation effects
oxidative damage
Oxidative stress
Oxidative Stress - drug effects
Pathogenesis
Polysaccharides
Pretreatment
Radiation damage
Reactive oxygen species
Reactive Oxygen Species - metabolism
Skin
Skin - drug effects
Skin - metabolism
Skin - radiation effects
Superoxide dismutase
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Summary:Although blue light can damage the skin to a certain extent, the pathogenesis of its damage remains still unclear. The available evidence suggests that oxidative stress may be the main cause of its damage. Lycium barbarum polysaccharide (LBP) has antioxidative effects in a variety of cells. In this paper, we investigated the protective role of LBP and its mechanism of action related to mitophagy in blue‐light‐damaged skin cells. The findings indicated that in HaCaT cells and mouse skin, LBP pretreatment was effective in reducing blue‐light‐induced apoptosis and ameliorating the elevated level of cellular autophagy/mitophagy caused by excessive blue light exposure. The markers reactive oxygen species (ROS), superoxide dismutase (SOD), and malondialdehyde (MDA) were used to assess oxidative stress. LBP could effectively inhibit blue‐light‐induced oxidative stress. It was also found that blue light exposure caused mitochondrial dysfunction in HaCaT cells, including increased intracellular calcium ion levels and decreased mitochondrial membrane potential. LBP pretreatment significantly relieved mitochondrial dysfunction in HaCaT cells. These findings imply that LBP pretreatment protects skin cells from damage induced by blue light irradiation and that mitophagy may be a significant factor in skin photodamage. Lycium barbarum polysaccharide (LBP), the main active ingredient extracted from the traditional Chinese medicine Lycium barbarum, can ameliorate blue‐light‐induced skin damage in vitro and in vivo, which is closely related to its antioxidant effect involving mechanism of mitophagy.
ISSN:0031-8655
1751-1097
DOI:10.1111/php.13863