Unveiling the Role of the Properties of Magnetic Nanoparticles for Highly Efficient Low-Frequency Magneto-Mechanical Actuation of Biomolecules

The role of the properties of magnetic nanoparticles in the remote magneto-mechanical actuation of biomolecules under the influence of external magnetic fields is still of particular interest. Here, a specially designed strategy based on the mechanical destruction of short oligonucleotide duplexes i...

Full description

Saved in:
Bibliographic Details
Published in:The journal of physical chemistry letters 2023-10, Vol.14 (40), p.9112-9117
Main Authors: Nikitin, Aleksey A., Prishchepa, Anastasiia V., Rytov, Ruslan A., Chekhonin, Vladimir P., Abakumov, Maxim A.
Format: Article
Language:English
Subjects:
Physical Insights into Materials and Molecular Properties
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The role of the properties of magnetic nanoparticles in the remote magneto-mechanical actuation of biomolecules under the influence of external magnetic fields is still of particular interest. Here, a specially designed strategy based on the mechanical destruction of short oligonucleotide duplexes is used to demonstrate the effect of magnetic nanoparticles with different sizes (5–99 nm) on the magnitude of the magneto-mechanical actuations in a low-frequency alternating magnetic field. The results show that the mechanical destruction of complementary chains of duplexes, caused by the rotational–vibrational movements of nanoparticles upon exposure to a magnetic field, has a nonmonotonic dependence on the nanoparticle core size. The main hypothesis of this phenomenon is associated with a key role of magneto-dipole interactions between individual nanoparticles, which blocks the movements of nanoparticles in dense clusters. This result will allow fine-tuning of the magnetic nanoparticle properties for addressing specific magneto-mechanical tasks.
ISSN:1948-7185
1948-7185
DOI:10.1021/acs.jpclett.3c01944