Silencing of heat shock factor 1 ( HSF1 ) inhibits proliferation, invasion, and epithelial‐mesenchymal transition in oral squamous cell carcinoma

Abstract Background Oral squamous cell carcinoma is characterized by high rates of morbidity and mortality. Evidence obtained for different types of cancer shows that tumor initiation, progression, and therapeutic resistance are regulated by heat shock factor 1. This research aimed to analyze the ef...

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Bibliographic Details
Published in:Journal of oral pathology & medicine 2023-11, Vol.52 (10), p.961-970
Main Authors: da Silva, Luiz Arthur Barbosa, da Costa, Lucas Melo, Massetti, Ana Camila Pereira, de Lucena Pereira, Laudenice, da Silveira, Ericka Janine Dantas, Salo, Tuula Anneli, Coletta, Ricardo Della, da Costa Miguel, Márcia Cristina
Format: Article
Language:English
Subjects:
Cancer
Cell cycle
Cell proliferation
G1 phase
Gene silencing
Heat shock factors
HSF1 protein
Keratinocytes
Morbidity
Oral cancer
Oral carcinoma
Oral squamous cell carcinoma
Squamous cell carcinoma
Tongue
Tumor microenvironment
Tumors
Vimentin
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Summary:Abstract Background Oral squamous cell carcinoma is characterized by high rates of morbidity and mortality. Evidence obtained for different types of cancer shows that tumor initiation, progression, and therapeutic resistance are regulated by heat shock factor 1. This research aimed to analyze the effects of heat shock factor 1 on the biological behavior of oral squamous cell carcinoma. Methods Clinicopathological and immunoexpression study of heat shock factor 1 in 70 cases of oral tongue SCC and functional assays by gene silencing of this factor in an oral tongue SCC cell line. Results Heat shock factor 1 was overexpressed in oral tongue SCC specimens compared to normal oral mucosa ( p  
ISSN:0904-2512
1600-0714
DOI:10.1111/jop.13491