Efficacy of a Novel Electroconductive Matrix To Treat Muscle Atrophy and Fat Accumulation in Chronic Massive Rotator Cuff Tears of the Shoulder

The high retear rate after a successful repair of the rotator cuff (RC) is a major clinical challenge. Muscle atrophy and fat accumulation of RC muscles over time adversely affect the rate of retear. Since current surgical techniques do not improve muscle degenerative conditions, new treatments are...

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Bibliographic Details
Published in:ACS biomaterials science & engineering 2023-10, Vol.9 (10), p.5782-5792
Main Authors: Shemshaki, Nikoo Saveh, Kan, Ho-Man, Barajaa, Mohammed A., Lebaschi, Amir, Otsuka, Takayoshi, Mishra, Neha, Nair, Lakshmi S., Laurencin, Cato T.
Format: Article
Language:English
Subjects:
Tissue Engineering and Regenerative Medicine
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Summary:The high retear rate after a successful repair of the rotator cuff (RC) is a major clinical challenge. Muscle atrophy and fat accumulation of RC muscles over time adversely affect the rate of retear. Since current surgical techniques do not improve muscle degenerative conditions, new treatments are being developed to reduce muscle atrophy and fat accumulation. In the previous study, we have shown the efficacy of aligned electroconductive nanofibrous fabricated by coating poly­(3,4-ethylene dioxythiophene): poly­(styrenesulfonate) (PEDOT:PSS) nanoparticles onto aligned poly­(ε-caprolactone) (PCL) electrospun nanofibers (PEDOT:PSS matrix) to reduce muscle atrophy in acute and subacute models of RC tears (RCTs). In this study, we further evaluated the efficacy of the PEDOT:PSS matrix to reduce muscle atrophy and fat accumulation in a rat model of chronic massive full-thickness RCTs (MRCTs). The matrices were transplanted on the myotendinous junction to the belly of the supraspinatus and infraspinatus muscles at 16 weeks after MRCTs. The biomechanics and histological assessments showed the potential of the PEDOT:PSS matrix to suppress the progression of muscle atrophy, fat accumulation, and fibrosis in both supraspinatus and infraspinatus muscles at 24 and 32 weeks after MRCTs. We also demonstrated that the PEDOT:PSS matrix implantation significantly improved the tendon morphology and tensile properties compared with current surgical techniques.
ISSN:2373-9878
2373-9878
DOI:10.1021/acsbiomaterials.3c00585