Adverse Pregnancy Outcomes Among Women with Human Immunodeficiency Virus Taking Isoniazid Preventive Therapy During the First Trimester

Abstract Background Isoniazid preventive therapy (IPT) is recommended for tuberculosis prevention yet data on the safety of first-trimester pregnancy exposure are limited. Methods Planned secondary analysis in a TB prevention trial of adverse pregnancy outcomes among participants assigned to 9-month...

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Bibliographic Details
Published in:Clinical infectious diseases 2024-03, Vol.78 (3), p.667-673
Main Authors: Gupta, Amita, Hughes, Michael D, Cruz, Jorge Leon, Avihingsanon, Anchalee, Mwelase, Noluthando, Severe, Patrice, Omoz-Oarhe, Ayotunde, Masheto, Gaerolwe, Moran, Laura, Benson, Constance A, Chaisson, Richard E, Swindells, Susan
Format: Article
Language:English
Subjects:
Abortion, Spontaneous - chemically induced
Abortion, Spontaneous - epidemiology
Antitubercular Agents - adverse effects
Female
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - prevention & control
Humans
Infant
Infant, Newborn
Isoniazid - adverse effects
Pregnancy
Pregnancy Outcome
Pregnancy Trimester, First
Premature Birth - epidemiology
Tuberculosis - drug therapy
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Summary:Abstract Background Isoniazid preventive therapy (IPT) is recommended for tuberculosis prevention yet data on the safety of first-trimester pregnancy exposure are limited. Methods Planned secondary analysis in a TB prevention trial of adverse pregnancy outcomes among participants assigned to 9-month IPT who became pregnant during (IPT-exposed) or after (unexposed) IPT. Regression models compared binary outcomes of a composite adverse outcome (any non-live birth, excluding induced abortion); preterm delivery
ISSN:1058-4838
1537-6591
1537-6591
DOI:10.1093/cid/ciad583