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Predictive factors to estimate the severity of nonalcoholic fatty liver disease in candidates for Roux-en-Y gastric bypass
•Hyperferritinemia was higher in individuals with severe non-alcoholic fatty liver disease.•An increase of 1 ng/mL in vitamin D level may reduce severe steatosis by 10%.•An increase of 1 U/L of alanine aminotransferase increases the chances of severe steatosis by 13%.•Predictive factors of severe no...
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| Published in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2023-12, Vol.116, p.112190-112190, Article 112190 |
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| container_title | Nutrition (Burbank, Los Angeles County, Calif.) |
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| creator | Gebara, Telma Souza e Silva Felicidade, Ingrid Costa, Giselle Nobre de Ramos, Marilia Zaparolli Bonde, Ana Carolina Palermo, Giovani Guemra, Samuel Peres, José Henrique de Souza Mantovani, Mário Sérgio Napoli, Rodrigo Picheth Di Campos, Antônio Carlos Ligocki |
| description | •Hyperferritinemia was higher in individuals with severe non-alcoholic fatty liver disease.•An increase of 1 ng/mL in vitamin D level may reduce severe steatosis by 10%.•An increase of 1 U/L of alanine aminotransferase increases the chances of severe steatosis by 13%.•Predictive factors of severe non-alcoholic fatty liver disease improve monitoring of patients who are obese.
Non-alcoholic fatty liver disease (NAFLD) is related to obesity, insulin resistance, dyslipidemia, and metabolic syndrome. The increasing prevalence of NAFLD results in a significant number of patients manifesting chronic liver disease over time. The aim of this study was to analyze the predictive factors to estimate NAFLD severity in patients who are candidates for Roux-en-Y gastric bypass.
This descriptive observational study was conducted with 136 obese patients who were candidates for Roux-en-Y gastric bypass and had mild, moderate, or severe NAFLD.
Severe NAFLD was more prevalent among the men (P = 0.007), and mild NAFLD was more prevalent among the women (P = 0.007). Hyperferritinemia was observed in the group with severe NAFLD (P = 0.01). Neck circumference and waist-to-height ratio were associated with an increased risk when comparing the groups with mild and severe NAFLD and those with moderate and severe NAFLD (P = 0.023 and P = 0.001, respectively); the alanine aminotransferase (ALT) and aspartate aminotransferase ratio values were >1 (P = 0.002) in the same comparisons. The regression analyses showed that an increase of 1 ng/mL in vitamin D reduced the chances of severe steatosis by 10% (P = 0.043), and an increase of 1 U/L ALT increased the chances of severe steatosis by 13% (P = 0.002).
High neck circumference and low waist-to-height ratio values, male sex, hyperferritinemia, increased serum ALT values, and decreased vitamin D levels were related to the risk for severe NAFLD. |
| doi_str_mv | 10.1016/j.nut.2023.112190 |
| format | article |
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Non-alcoholic fatty liver disease (NAFLD) is related to obesity, insulin resistance, dyslipidemia, and metabolic syndrome. The increasing prevalence of NAFLD results in a significant number of patients manifesting chronic liver disease over time. The aim of this study was to analyze the predictive factors to estimate NAFLD severity in patients who are candidates for Roux-en-Y gastric bypass.
This descriptive observational study was conducted with 136 obese patients who were candidates for Roux-en-Y gastric bypass and had mild, moderate, or severe NAFLD.
Severe NAFLD was more prevalent among the men (P = 0.007), and mild NAFLD was more prevalent among the women (P = 0.007). Hyperferritinemia was observed in the group with severe NAFLD (P = 0.01). Neck circumference and waist-to-height ratio were associated with an increased risk when comparing the groups with mild and severe NAFLD and those with moderate and severe NAFLD (P = 0.023 and P = 0.001, respectively); the alanine aminotransferase (ALT) and aspartate aminotransferase ratio values were >1 (P = 0.002) in the same comparisons. The regression analyses showed that an increase of 1 ng/mL in vitamin D reduced the chances of severe steatosis by 10% (P = 0.043), and an increase of 1 U/L ALT increased the chances of severe steatosis by 13% (P = 0.002).
High neck circumference and low waist-to-height ratio values, male sex, hyperferritinemia, increased serum ALT values, and decreased vitamin D levels were related to the risk for severe NAFLD.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2023.112190</identifier><language>eng</language><publisher>Kidlington: Elsevier Inc</publisher><subject>Alanine ; Alanine transaminase ; Aminotransferases ; Aspartate aminotransferase ; Body fat ; Body mass index ; Calciferol ; Decision trees ; Developing countries ; Diabetes ; Dyslipidemia ; Fatty liver ; Gastric bypass ; Gastrointestinal surgery ; Glucose ; Hyperferritinemia ; Insulin ; Insulin resistance ; LDCs ; Liver ; Liver diseases ; Liver fibrosis ; Metabolic disorders ; Metabolic syndrome ; Metabolism ; Obesity ; Observational studies ; Regression analysis ; Sex ratio ; Steatosis ; Transaminases ; Ultrasonic imaging ; Vitamin D ; Women</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2023-12, Vol.116, p.112190-112190, Article 112190</ispartof><rights>2023 Elsevier Inc.</rights><rights>2023. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c310t-a3fabc7b688f8289edf24af831e8f7cfa01fd9c31ce08d1fa5dfd97ee991aa7a3</cites><orcidid>0000-0002-6930-2299 ; 0000-0003-1938-6268 ; 0000-0001-6231-9445 ; 0000-0003-0211-7547</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids></links><search><creatorcontrib>Gebara, Telma Souza e Silva</creatorcontrib><creatorcontrib>Felicidade, Ingrid</creatorcontrib><creatorcontrib>Costa, Giselle Nobre</creatorcontrib><creatorcontrib>de Ramos, Marilia Zaparolli</creatorcontrib><creatorcontrib>Bonde, Ana Carolina</creatorcontrib><creatorcontrib>Palermo, Giovani</creatorcontrib><creatorcontrib>Guemra, Samuel</creatorcontrib><creatorcontrib>Peres, José Henrique de Souza</creatorcontrib><creatorcontrib>Mantovani, Mário Sérgio</creatorcontrib><creatorcontrib>Napoli, Rodrigo Picheth Di</creatorcontrib><creatorcontrib>Campos, Antônio Carlos Ligocki</creatorcontrib><title>Predictive factors to estimate the severity of nonalcoholic fatty liver disease in candidates for Roux-en-Y gastric bypass</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><description>•Hyperferritinemia was higher in individuals with severe non-alcoholic fatty liver disease.•An increase of 1 ng/mL in vitamin D level may reduce severe steatosis by 10%.•An increase of 1 U/L of alanine aminotransferase increases the chances of severe steatosis by 13%.•Predictive factors of severe non-alcoholic fatty liver disease improve monitoring of patients who are obese.
Non-alcoholic fatty liver disease (NAFLD) is related to obesity, insulin resistance, dyslipidemia, and metabolic syndrome. The increasing prevalence of NAFLD results in a significant number of patients manifesting chronic liver disease over time. The aim of this study was to analyze the predictive factors to estimate NAFLD severity in patients who are candidates for Roux-en-Y gastric bypass.
This descriptive observational study was conducted with 136 obese patients who were candidates for Roux-en-Y gastric bypass and had mild, moderate, or severe NAFLD.
Severe NAFLD was more prevalent among the men (P = 0.007), and mild NAFLD was more prevalent among the women (P = 0.007). Hyperferritinemia was observed in the group with severe NAFLD (P = 0.01). Neck circumference and waist-to-height ratio were associated with an increased risk when comparing the groups with mild and severe NAFLD and those with moderate and severe NAFLD (P = 0.023 and P = 0.001, respectively); the alanine aminotransferase (ALT) and aspartate aminotransferase ratio values were >1 (P = 0.002) in the same comparisons. The regression analyses showed that an increase of 1 ng/mL in vitamin D reduced the chances of severe steatosis by 10% (P = 0.043), and an increase of 1 U/L ALT increased the chances of severe steatosis by 13% (P = 0.002).
High neck circumference and low waist-to-height ratio values, male sex, hyperferritinemia, increased serum ALT values, and decreased vitamin D levels were related to the risk for severe NAFLD.</description><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Aminotransferases</subject><subject>Aspartate aminotransferase</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Calciferol</subject><subject>Decision trees</subject><subject>Developing countries</subject><subject>Diabetes</subject><subject>Dyslipidemia</subject><subject>Fatty liver</subject><subject>Gastric bypass</subject><subject>Gastrointestinal surgery</subject><subject>Glucose</subject><subject>Hyperferritinemia</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>LDCs</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Liver fibrosis</subject><subject>Metabolic disorders</subject><subject>Metabolic 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Roux-en-Y gastric bypass</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><date>2023-12</date><risdate>2023</risdate><volume>116</volume><spage>112190</spage><epage>112190</epage><pages>112190-112190</pages><artnum>112190</artnum><issn>0899-9007</issn><eissn>1873-1244</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>ObjectType-Undefined-3</notes><abstract>•Hyperferritinemia was higher in individuals with severe non-alcoholic fatty liver disease.•An increase of 1 ng/mL in vitamin D level may reduce severe steatosis by 10%.•An increase of 1 U/L of alanine aminotransferase increases the chances of severe steatosis by 13%.•Predictive factors of severe non-alcoholic fatty liver disease improve monitoring of patients who are obese.
Non-alcoholic fatty liver disease (NAFLD) is related to obesity, insulin resistance, dyslipidemia, and metabolic syndrome. The increasing prevalence of NAFLD results in a significant number of patients manifesting chronic liver disease over time. The aim of this study was to analyze the predictive factors to estimate NAFLD severity in patients who are candidates for Roux-en-Y gastric bypass.
This descriptive observational study was conducted with 136 obese patients who were candidates for Roux-en-Y gastric bypass and had mild, moderate, or severe NAFLD.
Severe NAFLD was more prevalent among the men (P = 0.007), and mild NAFLD was more prevalent among the women (P = 0.007). Hyperferritinemia was observed in the group with severe NAFLD (P = 0.01). Neck circumference and waist-to-height ratio were associated with an increased risk when comparing the groups with mild and severe NAFLD and those with moderate and severe NAFLD (P = 0.023 and P = 0.001, respectively); the alanine aminotransferase (ALT) and aspartate aminotransferase ratio values were >1 (P = 0.002) in the same comparisons. The regression analyses showed that an increase of 1 ng/mL in vitamin D reduced the chances of severe steatosis by 10% (P = 0.043), and an increase of 1 U/L ALT increased the chances of severe steatosis by 13% (P = 0.002).
High neck circumference and low waist-to-height ratio values, male sex, hyperferritinemia, increased serum ALT values, and decreased vitamin D levels were related to the risk for severe NAFLD.</abstract><cop>Kidlington</cop><pub>Elsevier Inc</pub><doi>10.1016/j.nut.2023.112190</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6930-2299</orcidid><orcidid>https://orcid.org/0000-0003-1938-6268</orcidid><orcidid>https://orcid.org/0000-0001-6231-9445</orcidid><orcidid>https://orcid.org/0000-0003-0211-7547</orcidid></addata></record> |
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| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2023-12, Vol.116, p.112190-112190, Article 112190 |
| issn | 0899-9007 1873-1244 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Alanine Alanine transaminase Aminotransferases Aspartate aminotransferase Body fat Body mass index Calciferol Decision trees Developing countries Diabetes Dyslipidemia Fatty liver Gastric bypass Gastrointestinal surgery Glucose Hyperferritinemia Insulin Insulin resistance LDCs Liver Liver diseases Liver fibrosis Metabolic disorders Metabolic syndrome Metabolism Obesity Observational studies Regression analysis Sex ratio Steatosis Transaminases Ultrasonic imaging Vitamin D Women |
| title | Predictive factors to estimate the severity of nonalcoholic fatty liver disease in candidates for Roux-en-Y gastric bypass |
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