Predictive factors to estimate the severity of nonalcoholic fatty liver disease in candidates for Roux-en-Y gastric bypass

•Hyperferritinemia was higher in individuals with severe non-alcoholic fatty liver disease.•An increase of 1 ng/mL in vitamin D level may reduce severe steatosis by 10%.•An increase of 1 U/L of alanine aminotransferase increases the chances of severe steatosis by 13%.•Predictive factors of severe no...

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Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2023-12, Vol.116, p.112190-112190, Article 112190
Main Authors: Gebara, Telma Souza e Silva, Felicidade, Ingrid, Costa, Giselle Nobre, de Ramos, Marilia Zaparolli, Bonde, Ana Carolina, Palermo, Giovani, Guemra, Samuel, Peres, José Henrique de Souza, Mantovani, Mário Sérgio, Napoli, Rodrigo Picheth Di, Campos, Antônio Carlos Ligocki
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
Aminotransferases
Aspartate aminotransferase
Body fat
Body mass index
Calciferol
Decision trees
Developing countries
Diabetes
Dyslipidemia
Fatty liver
Gastric bypass
Gastrointestinal surgery
Glucose
Hyperferritinemia
Insulin
Insulin resistance
LDCs
Liver
Liver diseases
Liver fibrosis
Metabolic disorders
Metabolic syndrome
Metabolism
Obesity
Observational studies
Regression analysis
Sex ratio
Steatosis
Transaminases
Ultrasonic imaging
Vitamin D
Women
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Summary:•Hyperferritinemia was higher in individuals with severe non-alcoholic fatty liver disease.•An increase of 1 ng/mL in vitamin D level may reduce severe steatosis by 10%.•An increase of 1 U/L of alanine aminotransferase increases the chances of severe steatosis by 13%.•Predictive factors of severe non-alcoholic fatty liver disease improve monitoring of patients who are obese. Non-alcoholic fatty liver disease (NAFLD) is related to obesity, insulin resistance, dyslipidemia, and metabolic syndrome. The increasing prevalence of NAFLD results in a significant number of patients manifesting chronic liver disease over time. The aim of this study was to analyze the predictive factors to estimate NAFLD severity in patients who are candidates for Roux-en-Y gastric bypass. This descriptive observational study was conducted with 136 obese patients who were candidates for Roux-en-Y gastric bypass and had mild, moderate, or severe NAFLD. Severe NAFLD was more prevalent among the men (P = 0.007), and mild NAFLD was more prevalent among the women (P = 0.007). Hyperferritinemia was observed in the group with severe NAFLD (P = 0.01). Neck circumference and waist-to-height ratio were associated with an increased risk when comparing the groups with mild and severe NAFLD and those with moderate and severe NAFLD (P = 0.023 and P = 0.001, respectively); the alanine aminotransferase (ALT) and aspartate aminotransferase ratio values were >1 (P = 0.002) in the same comparisons. The regression analyses showed that an increase of 1 ng/mL in vitamin D reduced the chances of severe steatosis by 10% (P = 0.043), and an increase of 1 U/L ALT increased the chances of severe steatosis by 13% (P = 0.002). High neck circumference and low waist-to-height ratio values, male sex, hyperferritinemia, increased serum ALT values, and decreased vitamin D levels were related to the risk for severe NAFLD.
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2023.112190