The effect of photodynamic therapy in controlling the oral biofilm: A comprehensive overview

Several resistance mechanisms are involved in dental caries, including oral biofilms. An accumulation of bacteria on the surface of teeth is called plaque. Periodontitis and gingivitis are caused by dental plaque. In this review article, we aimed to review the studies associated with the application...

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Bibliographic Details
Published in:Journal of basic microbiology 2023-12, Vol.63 (12), p.1319-1347
Main Authors: Aghili, Seyedeh Sara, Jahangirnia, Alireza, Alam, Mostafa, Oskouei, Asal Bagherzadeh, Golkar, Mohsen, Badkoobeh, Ashkan, Abbasi, Kamyar, Mohammadikhah, Meysam, Karami, Shahryar, Soufdoost, Reza Sayyad, Namanloo, Reza Abdollahi, Talebi, Sahar, Amookhteh, Samira, Hemmat, Maryam, Sadeghi, Sima
Format: Article
Language:English
Subjects:
antimicrobial
caries
oral biofilm
photodynamic
photosensitizer
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Summary:Several resistance mechanisms are involved in dental caries, including oral biofilms. An accumulation of bacteria on the surface of teeth is called plaque. Periodontitis and gingivitis are caused by dental plaque. In this review article, we aimed to review the studies associated with the application of photodynamic therapy (PDT) to prevent and treat various microbial biofilm‐caused oral diseases in recent decades. There are several studies published in PubMed that have described antimicrobial photodynamic therapy (APDT) effects on microorganisms. Several in vitro and in vivo studies have demonstrated the potential of APDT for treating endodontic, periodontal, and mucosal infections caused by bacteria as biofilms. Reactive oxygen species (ROS) are activated in the presence of oxygen by integrating a nontoxic photosensitizer (PS) with appropriate wavelength visible light. By causing irreversible damage to microorganisms, ROS induces some biological and photochemical events. Testing several wavelengths has been conducted to identify potential PS for APDT. A standard protocol is not yet available, and the current review summarizes findings from dental studies on APDT.
ISSN:0233-111X
1521-4028
DOI:10.1002/jobm.202300400