Prenatal Brain Maturation is Delayed in Neonates with Congenital Diaphragmatic Hernia

To assess brain development in fetuses with congenital diaphragmatic hernia (CDH) using a fetal Total Maturation Score (fTMS). This is a retrospective cohort study using data from a single-center clinical registry. Neonates with an antenatal diagnosis of CDH between 2014 and 2020 and prenatal brain...

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Bibliographic Details
Published in:The Journal of pediatrics 2024-01, Vol.264, p.113738-113738, Article 113738
Main Authors: Johng, Sandy, Licht, Daniel J., Hedrick, Holly L., Rintoul, Natalie, Linn, Rebecca L., Gebb, Juliana S., Xiao, Rui, Massey, Shavonne L.
Format: Article
Language:English
Subjects:
Brain - diagnostic imaging
Female
fetal
Hernias, Diaphragmatic, Congenital - diagnostic imaging
Hernias, Diaphragmatic, Congenital - therapy
Humans
Infant, Newborn
neuroimaging
Placenta
Pregnancy
Prenatal Diagnosis
Retrospective Studies
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Summary:To assess brain development in fetuses with congenital diaphragmatic hernia (CDH) using a fetal Total Maturation Score (fTMS). This is a retrospective cohort study using data from a single-center clinical registry. Neonates with an antenatal diagnosis of CDH between 2014 and 2020 and prenatal brain magnetic resonance imaging (MRI) (n = 48) were included. We compared our study sample with historical healthy controls (n = 48). The relationship between fTMS and gestational age (GA), as well as the association between fTMS and key prenatal variables and placental pathologic findings, were evaluated. Compared with healthy controls, neonates with CDH had a significant delay in fTMS (P value
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2023.113738