Rapid eye movement sleep affects interictal epileptic activity differently in mesiotemporal and neocortical areas

Objective Rapid eye movement (REM) sleep reduces the rate and extent of interictal epileptiform discharges (IEDs). Breakthrough epileptic activity during REM sleep is therefore thought to best localize the seizure onset zone (SOZ). We utilized polysomnography combined with direct cortical recordings...

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Published in:Epilepsia (Copenhagen) 2023-11, Vol.64 (11), p.3036-3048
Main Authors: Ho, Alyssa, Hannan, Sana, Thomas, John, Avigdor, Tamir, Abdallah, Chifaou, Dubeau, François, Gotman, Jean, Frauscher, Birgit
Format: Article
Language:English
Subjects:
EEG
Epilepsy
Eye movements
Firing pattern
interictal activity
Localization
NREM sleep
rapid eye movement
REM sleep
Seizures
Sleep
Sleep and wakefulness
stereo‐electroencephalography
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Summary:Objective Rapid eye movement (REM) sleep reduces the rate and extent of interictal epileptiform discharges (IEDs). Breakthrough epileptic activity during REM sleep is therefore thought to best localize the seizure onset zone (SOZ). We utilized polysomnography combined with direct cortical recordings to investigate the influences of anatomical locations and the time of night on the suppressive effect of REM sleep on IEDs. Methods Forty consecutive patients with drug‐resistant focal epilepsy underwent combined polysomnography and stereo‐electroencephalography during presurgical evaluation. Ten‐minute interictal epochs were selected 2 h prior to sleep onset (wakefulness), and from the first and second half of the night during non‐REM (NREM) sleep and REM sleep. IEDs were detected automatically across all channels. Anatomic localization, time of night, and channel type (within or outside the SOZ) were tested as modulating factors. Results Relative to wakefulness, there was a suppression of IEDs by REM sleep in neocortical regions (median = −27.6%), whereas mesiotemporal regions showed an increase in IEDs (19.1%, p = .01, d = .39). This effect was reversed when comparing the regional suppression of IEDs by REM sleep relative to NREM sleep (−35.1% in neocortical, −58.7% in mesiotemporal, p 
ISSN:0013-9580
1528-1167
DOI:10.1111/epi.17763