PAPRIKA: A Question Bank for Assessing Psoriatic Arthritis Risk in Individuals of Diverse Ancestries

Objective We aimed to create a question bank about clinical factors for predicting the diagnoses of psoriatic arthritis in patients with psoriasis of various ancestries and skin tones, which can be completed entirely by patients. Methods Utah Psoriasis Initiative participants without a psoriatic art...

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Bibliographic Details
Published in:Arthritis care & research (2010) 2024-03, Vol.76 (3), p.421-425
Main Authors: Walsh, Jessica A., Carroll, Courtney, Callis Duffin, Kristina, Wang, Jing, Krueger, Gerald G., Feng, Bing‐Jian
Format: Article
Language:English
Subjects:
Arthritis, Psoriatic - diagnosis
Arthritis, Psoriatic - drug therapy
Arthritis, Psoriatic - epidemiology
Capsicum
Comorbidity
Diagnosis
Fingernail
Genealogy
Humans
Literature reviews
Psoriasis
Psoriasis - diagnosis
Psoriasis - drug therapy
Psoriasis - epidemiology
Psoriatic arthritis
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Summary:Objective We aimed to create a question bank about clinical factors for predicting the diagnoses of psoriatic arthritis in patients with psoriasis of various ancestries and skin tones, which can be completed entirely by patients. Methods Utah Psoriasis Initiative participants without a psoriatic arthritis diagnosis at enrollment were observed for diagnosis during the study period. We inferred ancestry from exome sequencing data and performed Cox proportional hazards regression to identify clinical predictors of psoriatic arthritis in different ancestry groups. Based on results and literature review, we developed a question bank for assessing psoriatic arthritis risk among patients with psoriasis in various ancestries. Results Patient‐reported untreated psoriasis induration and history of fingernail psoriasis were associated with psoriatic arthritis in participants of European and non‐European ancestry. We developed the Psoriatic Arthritis Prediction and Identification Question Bank for Diverse Ancestries (PAPRIKA) version 1.0, which included questions regarding psoriasis characteristics, arthritis symptoms, comorbidities, family history, and demographics. PAPRIKA is accessible at http://bjfenglab.org/. Conclusion The clinical features (untreated psoriasis induration and history of fingernail psoriasis) that can predict psoriatic arthritis in European individuals also work for non‐European individuals. PAPRIKA can be used to gather psoriatic arthritis predictive data from patients with psoriasis without provider assistance and is relevant for patients across ancestries.
ISSN:2151-464X
2151-4658
DOI:10.1002/acr.25232