Cardiovascular evaluation and endothelial dysfunction in Cushing syndrome following remission: a prospective study

Purpose Cushing syndrome (CS) is a well-known risk factor for cardiovascular morbidities. We aimed to evaluate endothelial and cardiovascular functions, endothelial mediators and pro-inflammatory cytokines in patients with CS before and after remission. Methods Adult patients with newly diagnosed en...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2024-03, Vol.47 (3), p.645-653
Main Authors: Hacioglu, A., Firat, S. T., Caglar, A. S., Karaca, Z., Kalay, N., Taheri, S., Tanriverdi, F., Selcuklu, A., Unluhizarci, K., Kelestimur, F.
Format: Article
Language:English
Subjects:
Adrenocorticotropic hormone
Adult
Blood pressure
Blood Pressure Monitoring, Ambulatory
Body mass index
Cardiovascular diseases
Carotid Intima-Media Thickness
Cholesterol
Cushing syndrome
Cushing Syndrome - complications
Cushing Syndrome - surgery
Cytokines
Echocardiography
Endocrinology
Endothelin 1
Humans
IL-1β
Inflammation
Internal Medicine
Low density lipoprotein
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Middle Aged
Nervous system diseases
Original Article
Pituitary
Prospective Studies
Remission
Risk factors
Tumor Necrosis Factor-alpha
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Vascular Diseases
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Summary:Purpose Cushing syndrome (CS) is a well-known risk factor for cardiovascular morbidities. We aimed to evaluate endothelial and cardiovascular functions, endothelial mediators and pro-inflammatory cytokines in patients with CS before and after remission. Methods Adult patients with newly diagnosed endogenous CS were included. Metabolic [body mass index (BMI), glucose, and lipid values] and cardiovascular evaluation studies [24-h ambulatory blood pressure monitoring, carotid intima-media thickness (CIMT), flow-mediated dilation (FMD), and echocardiography] were performed, and endothelial mediators [asymmetric dimethyl arginine (ADMA) and endothelin-1 (ET-1)] and pro-inflammatory cytokines [interleukin-1β (IL-1β) and tumor necrosis factor-alpha (TNF-α)] were measured. Control group was matched in terms of age, gender, and BMIs. Results Twenty-five patients, mean age 40.60 ± 14.04 years, completed the study. Compared to controls ( n  = 20) mean arterial pressure (MAP) and CIMT were higher ( p  
ISSN:1720-8386
0391-4097
1720-8386
DOI:10.1007/s40618-023-02183-4