Body composition changes and their relationship with obstructive sleep apnoea symptoms, severity: The Sleeping Well Trial

Obstructive sleep apnoea (OSA) and obesity share a complex bi-directional relationship as location of body fat and changes in regional body composition may be more important for OSA improvement than changes in total body weight only. The aim of this study was to evaluate the impact of a 6-month weig...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2023-09, Vol.42 (9), p.1661-1670
Main Authors: Day, Kaitlin, Nguo, Kay, A. Edwards, Bradley, M O'Driscoll, Denise, C Young, Alan, P Haines, Terry, S Hamilton, Garun, Ghazi, Ladan, Bristow, Claire, Truby, Helen
Format: Article
Language:English
Subjects:
Body composition
Obesity
Obstructive sleep apnoea
Sex differences
Waist circumference
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Summary:Obstructive sleep apnoea (OSA) and obesity share a complex bi-directional relationship as location of body fat and changes in regional body composition may be more important for OSA improvement than changes in total body weight only. The aim of this study was to evaluate the impact of a 6-month weight loss intervention for adults newly diagnosed with moderate-severe OSA and obesity on regional body composition. The secondary aims evaluated the relationship between changes in OSA symptoms and severity and anthropometry and regional body composition during the first 12-months after commencing CPAP and explored differences in outcomes between males and females. Participants (n = 59) received CPAP overnight at home alongside a 6-month modified fasting intervention with 12-months follow up. Regional body composition was measured by Dual X-ray absorptiometry, (DXA) and anthropometry before and after the lifestyle intervention. OSA severity was measured using the apnoea hypopnea index via overnight polysomnography and OSA symptoms were measured using the Epworth Sleepiness scale. Forty-seven adults (74% male) had complete measures available with a mean age of 50.0 y (SD 11.0) and BMI 34.1 kg/m2 (SD 5.0). Following the intervention average fat mass changed by −5.27 kg (5.36), p 
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2023.07.006