Reprogramming dendritic cells through the immunological synapse: A two‐way street

Abstract Dendritic cells (DCs) bridge innate and adaptive immunity. Their main function is to present antigens to prime T cells and initiate and shape adaptive responses. Antigen presentation takes place through intimate contacts between the two cells, termed immune synapses (IS). During the formati...

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Bibliographic Details
Published in:European journal of immunology 2023-11, Vol.53 (11), p.e2350393-e2350393
Main Authors: Calzada‐Fraile, Diego, Sánchez‐Madrid, Francisco
Format: Article
Language:English
Subjects:
Adaptive immunity
Antigen presentation
Cell surface receptors
Dendritic cells
Immunological synapses
Lymphocytes T
Synaptogenesis
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Summary:Abstract Dendritic cells (DCs) bridge innate and adaptive immunity. Their main function is to present antigens to prime T cells and initiate and shape adaptive responses. Antigen presentation takes place through intimate contacts between the two cells, termed immune synapses (IS). During the formation of IS, information travels towards the T‐cell side to induce and tune its activation; but it also travels in reverse via engagement of membrane receptors and within extracellular vesicles transferred to the DC. Such reverse information transfer and its consequences on DC fate have been largely neglected. Here, we review the events and effects of IS‐mediated antigen presentation on DCs. In addition, we discuss novel technological advancements that enable monitoring DCs interactions with T lymphocytes, the main effects of DCs undergoing productive IS (postsynaptic DCs, or psDCs), and how reverse information transfer could be harnessed to modulate immune responses for therapeutic intervention.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.202350393