Acyl CoA oxidase: from its expression, structure, folding, and import to its role in human health and disease

β-oxidation of fatty acids is an important metabolic pathway and is a shared function between mitochondria and peroxisomes in mammalian cells. On the other hand, peroxisomes are the sole site for the degradation of fatty acids in yeast. The first reaction of this pathway is catalyzed by the enzyme a...

Full description

Saved in:
Bibliographic Details
Published in:Molecular genetics and genomics : MGG 2023-11, Vol.298 (6), p.1247-1260
Main Authors: Kashyap, Isha, Deb, Rachayeeta, Battineni, Abhigna, Nagotu, Shirisha
Format: Article
Language:English
Subjects:
Acyl-CoA Oxidase - metabolism
Aging
Animal Genetics and Genomics
Animals
Biochemistry
Biodegradation
Biomedical and Life Sciences
Dehydrogenases
Enzymes
Fatty acids
Fatty Acids - metabolism
Gene expression
Genetics
Genomics
Human Genetics
Humans
Life Sciences
Lipids
Mammalian cells
Mammals
Metabolic pathways
Microbial Genetics and Genomics
Mitochondria
Oxidation
Oxidation-Reduction
Peroxisomes
Peroxisomes - genetics
Peroxisomes - metabolism
Plant Genetics and Genomics
Protein folding
Protein transport
Proteins
Review
Saccharomyces cerevisiae - metabolism
Yeast
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:β-oxidation of fatty acids is an important metabolic pathway and is a shared function between mitochondria and peroxisomes in mammalian cells. On the other hand, peroxisomes are the sole site for the degradation of fatty acids in yeast. The first reaction of this pathway is catalyzed by the enzyme acyl CoA oxidase housed in the matrix of peroxisomes. Studies in various model organisms have reported the conserved function of the protein in fatty acid oxidation. The importance of this enzyme is highlighted by the lethal conditions caused in humans due to its altered function. In this review, we discuss various aspects ranging from gene expression, structure, folding, and import of the protein in both yeast and human cells. Further, we highlight recent findings on the role of the protein in human health and aging, and discuss the identified mutations in the protein associated with debilitating conditions in patients.
ISSN:1617-4615
1617-4623
DOI:10.1007/s00438-023-02059-5