Cellulose microcrystalline: A promising ecofriendly approach to control Culex quinquefasciatus larvae

The growing use of synthetic chemical compounds/substances in vector control of mosquitoes, associated with their adverse effects on the environment and non-target organisms, has demanded the development of eco-friendly alternatives. In this context, this study aimed to evaluate the larvicidal actio...

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Published in:The Science of the total environment 2023-11, Vol.901, p.165952-165952, Article 165952
Main Authors: Souza, Sindoval Silva de, Gomes, Alex Rodrigues, Guimarães, Abraão Tiago Batista, Rodrigues, Aline Sueli de Lima, de Matos, Letícia Paiva, Dos Santos Mendonça, Juliana, da Luz, Thiarlen Marinho, Matos, Stênio Gonçalves da Silva, Rahman, M Safiur, Ragavendran, Chinnasamy, Senthil-Nathan, Sengottayan, Guru, Ajay, Rakib, Md Refat Jahan, Mubarak, Nabisab Mujawar, Rahman, Md Mostafizur, Rocha, Thiago Lopes, Islam, Abu Reza Md Towfiqul, Malafaia, Guilherme
Format: Article
Language:English
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Summary:The growing use of synthetic chemical compounds/substances in vector control of mosquitoes, associated with their adverse effects on the environment and non-target organisms, has demanded the development of eco-friendly alternatives. In this context, this study aimed to evaluate the larvicidal action of different cellulose microcrystalline (CMs) concentrations and investigate their toxicity mechanisms in Culex quinquefasciatus fourth instar larvae as a model species. Probit analysis revealed that the median lethal concentrations (LC ) for 24 h and 36 h exposure were 100 and 58.29 mg/L, respectively. We also showed that such concentrations induced a redox imbalance in the larvae, marked by an increase in the production of reactive oxygen species (ROS) and thiobarbituric acid reactive substances (TBARS), as well as a reduction in the activity of superoxide dismutase (SOD) and catalase (CAT). Furthermore, different alterations in the external morphology of the larvae were associated with the ingestion of CMs. On the other hand, exposure of adult zebrafish (Danio rerio) to LC 24h and LC 36h for seven days did not induce any behavioral changes or alterations mutagenic, genotoxic, biochemical, or in the production of cytokines IFN-γ and IL-10. Thus, taken together, our study demonstrates for the first time that the use of CMs can constitute a promising strategy in the control of C. quinquefasciatus larvae, combining insecticidal efficiency with an "eco-friendly" approach in the fight against an important mosquito vector of several human diseases.
ISSN:0048-9697
1879-1026
DOI:10.1016/j.scitotenv.2023.165952